中国临床药理学杂志2017，Vol.33Issue(23)：2339-2342,4.DOI:10.13699/j.cnki.1001-6821.2017.23.004
辛伐他汀片联合五苓散用于心脏瓣膜置换术术后的临床研究
Clinical trial of simvastatin tablets combined with Wuling powder in the treatment of heart valve replacement
摘要
Abstract
Objective To observe the clinical efficacy and safety of simvastatin tablets combined with Wuling powder in cardiac valve replacement.Methods A total of 100 patients with cardiac valve replacement were randomly divided into control group and treatment group with 50 cases per group.Control group was orally given simvastatin tablets 10 mg per time,bid,1 week before operation and from 2 days after operation for 1 week.Treatment group was orally given Wuling powder 6 g per time,tid,1 week before operation and from 2 days after operation for 1 week,on the basis of control group.The hemodynamic indexes,blood lipid indexes and adverse drug reactions were compared between two groups.Results Three days after operation,the main indexes in treatment and control groups were compared:whole high viscosity were (6.06 ±0.26) and (7.70 ±0.42) mPa · s,whole low viscosity were (10.31 ±0.35) and (12.30 ±0.38) mPa · s,plasma viscosity were (1.30 ± 0.23) and (2.69 ± 0.20) mPa · s,hematocrit were (46.59 ± 1.20) ％ and (52.97 ±0.65)％,with significant difference (all P ＜ 0.05).One week after operation,the main indexes in treatment and control groups were compared:total cholesterol were (5.62 ± 0.21) and (6.11 ± 0.27) mmol · L-1,triglyceride were (1.76 ± 0.21) and (2.26 ± 0.24) mmol · L-1,low density lipoprotein cholesterol were (2.23 ±0.21) and (2.87 ± 0.23) mmol · L-1,high density lipoprotein cholesterol were (1.18 + 0.07) and (0.94 ±0.06) mmol · L-1,with significant difference (all P ＜ 0.05).The adverse drug reactions in treatment group were abdominal pain,constipation and fatigue,which in control group were constipation and abdominal pain.The incidences of adverse drug reactions in treatment and control groups were 4.00％ and 6.00％ without significant difference (P ＞ 0.05).Conclusion Simvastatin tablets combined with Wuling powder can significantly improve hemodynamics and blood lipid in patients with cardiac valve replacement,without increasing the incidence of adverse drug reactions.关键词
辛伐他汀片/五苓散/心脏瓣膜置换术/血流动力学/血脂/安全性Key words
simvastatin tablet/Wuling powder/heart valve replacement/hemodynamics/blood lipid/safety分类
医药卫生引用本文复制引用
唐显虹,从丽,马卫东..辛伐他汀片联合五苓散用于心脏瓣膜置换术术后的临床研究[J].中国临床药理学杂志,2017,33(23):2339-2342,4.基金项目
贵州省科学技术基金资助项目(C030304) （C030304）
淮安市科技基金资助项目(2016BUMA0001) （2016BUMA0001）
