中国临床药理学杂志2017，Vol.33Issue(23)：2351-2353,3.DOI:10.13699/j.cnki.1001-6821.2017.23.007
氨甲环酸对肝癌患者肝切除手术出血量及术后凝血功能的影响
Effects of tranexamic acid on bleeding volume and postoperative coagulation function after liver resection in patients with hepatocellular carcinoma
摘要
Abstract
Objective To evaluate the effect of tranexamic acid on the blood loss and coagulation function after liver resection in patients with hepatocellular carcinoma (HCC).Methods Seventy patients with hepatectomy who underwent liver resection were randomly divided into control group and treatment group,each group 35 cases.Control group was given 0.9％ NaCl injection 10 mg · kg-1.Treatment group was given tranexamic acid 10 mg · kg-1.Two groups were used at half an hour before operation.The surgical bleeding volume and postoperative coagulation function between two groups were compared.Results The operation time,time of hilar occlusion in treatment group were (157.98 ±22.36),(30.14 ±5.64) min,had no significant difference with those in control group,which were (154.98 ± 23.65),(28.79 ± 5.79) min (P ＞ 0.05).The surgical blood transfusion,bleeding volume,infusion of erythrocyte suspension in treatment group were (879.65 ± 59.36) mL,(768.97 ± 45.65) mL,(1.36 ± 0.59) U,had significant differences with those in control group,which were (1054.91 ±61.32) mL,(869.64 ±46.69) mL,(2.01 ±0.65) U (all P ＜0.05).The percentage of activated thromboplastin (APTT),prothrombin time (PT),platelet (PLT) in treatment group at 24 h after operation were (41.56 ±5.46)s,(13.48 ±3.16)s,(167.89 ±35.87) × 109/L,had no significant difference with those in control group,which were (43.19 ± 5.69) s,(14.59 ± 2.49) s,(162.35 ± 41.59) × 109/L (all P ＞0.05).The fibrinogen (FIB) in treatment group and control group were (3.27 ±0.56),(3.01 ±0.59)g · L-1,with significant difference (P ＜ 0.05).There was no adverse drug reactions in two groups during the treatment.Conclusion Giving methotrexate injection to hepatocarcinoma patients before liver resection can reduce the amount of surgical bleeding,and improve the patients' postoperative coagulation function.关键词
氨甲环酸/肝癌/肝切除/手术出血量/术后凝血功能Key words
tranexamic acid/liver cancer/liver resection/bleeding volume/postoperative coagulation分类
医药卫生引用本文复制引用
王叙德,刘华高,方有智,孔胜兵,吴迅,胡永毅..氨甲环酸对肝癌患者肝切除手术出血量及术后凝血功能的影响[J].中国临床药理学杂志,2017,33(23):2351-2353,3.基金项目
安徽省高等学校省级质量工程基金资助项目(2013sxzx051) （2013sxzx051）
安徽省教育厅高等职业教育创新发展行动计划项目骨干专业基金资助项目(182-XM01) （182-XM01）
安徽省高校人文社科研究重点基金资助项目(SK2016A0339) （SK2016A0339）
