中国临床药理学杂志2017，Vol.33Issue(23)：2431-2433,3.DOI:10.13699/j.cnki.1001-6821.2017.23.030
美罗培南致住院患者急性肾损伤的药物不良反应分析
Analysis of adverse drug reactions induced by meropenem in inpatients with acute kidney injury
杜朝阳 1谢铮铮 2赵莹 1陈张勇 1李光耀 2孙路路1
作者信息
- 1. 首都医科大学附属北京世纪坛医院药剂科,北京100038
- 2. 北京大学药学院药事管理与临床药学系,北京100191
- 折叠
摘要
Abstract
Objective To explore the occurrence and related factors of acute kidney injury induced by meropenem in inpatients.Methods The clinical data of the 400 patients who were hospitalized in Beijing Shijitan Hospital in 2015 and received meropenem treatments were collected randomly and analyzed retrospectively.The main analytic indicators included the change of serum creatinine before and after meropenem treatment and the drug combinations.Through screening the cases conformed to the diagnosis of acute renal injury,and using the Naranjo algorithm to evaluate the correlation of meropenem and acute kidney injury to determine the drug-induced acute kidney injury patients (hereinafter referred to as the patients with acute kidney injury).Results A total of 375 patients were enrolled in this study.There were 8 (2.13％) patients in the acute kidney injury group and 367 patients in the no acute kidney injury group.It comprised 6 men with age of (72.83 ± 9.79) years,and 2 women with age of (84.50 ± 12.02) years in the acute kidney injury group;while it comprised 194 men with age of (80.24 ± 11.24) years,and 173 women with age of (77.84 ± 12.87) years in the no acute kidney injury group.There were no statistical significance in gender and age distribution in patients between the two groups (all P ＞ 0.05).The serum creatinine levels before meropenem treatment were (104.25 ± 53.22) μmol · L-1 in patients in the acute kidney injury group and (100.23 ± 14.54) μmol · L-1 in patients in the no acute kidney injury group.The difference was no statistical significance between the 2 groups (P ＞ 0.05).The serum creatinine levels increased to (304.38 ± 160.78) μmol · L-1 after (5.75 ± 2.86) days receiving meropenem treatments in patients in the acute kidney injury group.The difference before and after treatment was statistically significant(P ＜0.05).In the 8 patients with acute kidney injury,6 of them combined with nephrotoxic drug at the same time.When the acute kidney injury appeared in the 3 patients,meropenem was stopped immediately and changed to other antibacterials.Conclusion Meropenem may induce acute kidney injury in inpatients,which may be related to the underlying disease and potential interactions among combined drugs.关键词
美罗培南/急性肾损害/药物不良反应/住院患者Key words
meropenem/acute kidney injury/adverse drug reaction/inpatient分类
医药卫生引用本文复制引用
杜朝阳,谢铮铮,赵莹,陈张勇,李光耀,孙路路..美罗培南致住院患者急性肾损伤的药物不良反应分析[J].中国临床药理学杂志,2017,33(23):2431-2433,3.
