中国临床药理学杂志2017，Vol.33Issue(23)：2443-2445,3.DOI:10.13699/j.cnki.1001-6821.2017.23.035
对头孢他啶注射液稳定性的影响因素研究
Effect on the stability of ceftazidime injection
摘要
Abstract
Objective To study the effect of temperature changes on the stability of ceftazidime in 0.9％ NaC1 injection and 5％ glucose injection.Methods The content of the drug in ceftazidime injection was measured at different temperatures (28,37 ℃) and different time (0,0.5,1,1.5,2,2.5,3,4,5,6,24,30,48 h).Results The results of stability of ceftazidime injection at 28 ℃ and 37 ℃ indicated that the drug content of ceftazidime injection decreased and the degradation product increased with the prolongation of time.The injection was amber yellow from clear and transparent.Conclusion Ceftazidime injection should not be stored for more than 5 hours in high temperature,or there will be adverse drug reactions in clinical application.Therefore,in actual use,we should pay special attention to storage conditions,the temperature should not be too high,and it is best to match the current use.关键词
头孢他啶注射液/稳定性/温度Key words
ceftazidime injection/stability/temperature分类
医药卫生引用本文复制引用
郑晨,王钰,何晓静,李晓冰,菅凌燕..对头孢他啶注射液稳定性的影响因素研究[J].中国临床药理学杂志,2017,33(23):2443-2445,3.基金项目
辽宁省自然科学基金资助项目(2014021090) （2014021090）
