中国临床药理学杂志2017，Vol.33Issue(23)：2446-2448,3.DOI:10.13699/j.cnki.1001-6821.2017.23.036
Castleman病的临床研究
Clinical analysis of Castleman's disease
摘要
Abstract
Objective To investigate the clinical manifestations,pathological characteristics,treatment and outcome of Castleman's disease (CD).Methods Retrospective analysis of clinical manifestations,laboratory examination,pathology and treatment of 10 patients with CD from March 2011 to May 2014 in our hospital was performed.Results 4 cases were males,6 cases were females,with a median age of 44 years (30-71 years old).1 case was unicentric Castleman's disease (UCD),9 cases were multicentric Castleman's disease (MCD).3 cases were hyaline-vascular type and 7 cases in plasma cell type according to pathological classification,non mixed type.1 UCD case with HV type acquired remission after surgery.One case of MCD did not receive chemotherapy,eight cases were received chemotherapy,including one case of complete remission,6 cases of stable disease,one case of disease progression.None of the patients were transferred into lymphoma.The median follow-up time was 26.5 months (from 13 to 64 months),1 patient died,3-year probabilities overall survival was 84.3％.Conclusion CD had various symptoms and signs.It was diagnosed by pathology.The UCD was often asymptomatic and curable by surgical excision of the mass,while MCD had a less favorable prognosis by chemotherapy and chemotherapy combined with monoclonal antibodies.关键词
Castleman病/人类8型疱疹病毒/治疗/预后Key words
Castleman's disease/human herpesvirus type 8/treatment/prognosis分类
医药卫生引用本文复制引用
袁海龙,古力巴旦木·艾则孜,曲建华,曹海洲,段显琳,徐建丽,陈刚..Castleman病的临床研究[J].中国临床药理学杂志,2017,33(23):2446-2448,3.基金项目
新疆维吾尔自治区自然科学基金资助项目(2013211A100) （2013211A100）
