中国临床药理学杂志2017，Vol.33Issue(23)：2493-2496,4.DOI:10.13699/j.cnki.1001-6821.2017.23.049
糖尿病治疗药物改善阿尔兹海默病患者认知障碍的研究现状
Research progress on the role of antidiabetic drugs in treatment of cognitive deficits in patients with Alzheimer's disease
摘要
Abstract
Alzheimer's disease (AD)and type 2 diabetes mellitus (T2DM),causing by population ageing and changing lifestyles,have become latest threats to human health.Recent basic researches and clinical studies suggested that T2DM was a risk factor for cognitive impairment and dementia.Brain insulin signaling impairment and insulin metabolic disorders are often associated with patients with AD,indicating T2DM and AD share similar signaling pathways during pathological development.Therefore,the underlying mechanism involved in cognitive improvement of antidiabetic drugs (including insulin,glucagon-like peptide-1,thiazolidinediones and dipeptidyl peptidase-4 inhibitors) for AD patients are discussed in this review.关键词
阿尔兹海默病/认知障碍/2型糖尿病/糖尿病治疗药物Key words
Alzheimer's disease/cognitive deficits/type 2 diabetes mellitus/antidiabetic drug分类
医药卫生引用本文复制引用
赵鹤,邵华,牛一民,于锋..糖尿病治疗药物改善阿尔兹海默病患者认知障碍的研究现状[J].中国临床药理学杂志,2017,33(23):2493-2496,4.基金项目
江苏省自然科学基金青年项目(BK20160704) （BK20160704）
