中国临床药理学杂志2017，Vol.33Issue(24)：2559-2561,2565,4.DOI:10.13699/j.cnki.1001-6821.2017.24.001
孟鲁司特钠片联合布地奈德福莫特罗粉吸入剂治疗支气管哮喘的临床研究
Clinical trial of montelukast sodium tablets combined with budesonide and formoterol fumarate powder for inhalation in the treatment of bronchial asthma
摘要
Abstract
Objective To observe the clinical efficacy and safety of montelukast sodium tablets combined with budesonide and formoterol fumarate powder for inhalation in the treatment of bronchial asthma.Methods A total of 120 bronchial asthma patients were randomly divided into control group and treatment group with 60 cases per group.Control group was given budesonide and formoterol fumarate powder for inhalation 320 μg/9 μg every time,bid,oral inhalation.Treatment group was given montelukast sodium 10 mg every night,orally.Two groups were treated for 12 weeks.The clinical efficacy,pulmonary function and adverse drug reactions were compared between two groups.Results After treatment,the total effective rate of treatment group and control group were 93.33％(56 cases/60 cases) and 73.33％ (44 cases/60 cases) with significant difference (P ＜0.01).After treatment,the forced expiratory volume in 1 second,forced vital capacity and peak expiratory flow in treatment and control groups were (3.05 ± 0.76) and (2.54 ± 0.81) L,(4.34±0.92) and (3.59 ± 0.99) L,(5.08 ± 1.36) and (3.94 ± 1.22) L,with significant differences (all P ＜ 0.01).The adverse drug reactions in two groups were mainly concentrated on nausea,dry mouth,dizziness,drowsiness,diarrhea,vomiting.The incidences of adverse drug reactions in treatment and control groups were 30.00％ and 21.67％ without significant difference (P ＞ 0.05).Conclusion Montelukast sodium tablets combined with budesonide and formoterol fumarate powder for inhalation have a definitive clinical efficacy in the treatment of bronchial asthma,which can significantly improve the lung function,without increasing the incidences of adverse drug reactions.关键词
孟鲁司特钠片/布地奈德福莫特罗粉吸入剂/支气管哮喘/安全性Key words
montelukast sodium tablet/budesonide and formoterol fumarate powder for inhalation/bronchial asthma/safety分类
医药卫生引用本文复制引用
彭锦芸,吴李勇,肖建宏,魏丹东,曾林淼..孟鲁司特钠片联合布地奈德福莫特罗粉吸入剂治疗支气管哮喘的临床研究[J].中国临床药理学杂志,2017,33(24):2559-2561,2565,4.基金项目
福建省宁德市科学技术局计划基金资助项目(20140024) （20140024）
