中国临床药理学杂志2017，Vol.33Issue(24)：2572-2574,3.DOI:10.13699/j.cnki.1001-6821.2017.24.005
细胞色素P4503A4*1G与腺苷三磷酸结合转运蛋白G超家族成员2基因多态性对羟氯喹血药浓度的影响
Effects of cytochrome P 450 3A4 * 1G and ATP-binding cassette sub-family G member 2 polymorphisms on blood concentration of hydroxychloroquine
摘要
Abstract
Objective To study the correlation between cytochrome P (CYP) 450 3A4 and ATP-binding cassette sub-family G member 2 (ABCG2) genotypes and the concentration of hydroxychloroquine (HCQ) in systemic lupus erythematosus (SLE) patients.Methods Forty-six SLE were recruited and their blood HCQ concentrations were determined.The CYP3A4 * 1G (rs2242480) and ABCG2 (rs2231142) genotypes were analyzed by Sanger sequencing.The influences of these genotypes on the concentrations of HCQ were studied.Results The blood concentrations of patients with CYP3A4 * 1 G wild-type homozygous (* 1/* 1),heterozygous mutant (* 1/* 1G) and homozygous mutant (*1G/*1G) were (807.2±455.9),(705.4±331.9) and (229.5 ± 89.8) ng · mL-1.And the blood concentrations of GG,GT and TT genotypes of ABCG2 were (732.2 ±424.4),(764.5 ±371.9),(271.0 ±148.5) ng · mL-1.No significant difference could be shown in patients with ABCG2 genotypes (P ＞ 0.05).Conclusion In SLE therapy,patients with CYP3A4 * 1G gene exhibit lower blood concentrations than the non-carriers.The single nucleotide polymorphisms (SNPs)ABCG2 do not affect the blood concentration and efficacy of HCQ.关键词
基因多态性/细胞色素P450 3A4/腺苷三磷酸结合转运蛋白G超家族成员2/羟氯喹Key words
polymorphism/cytochrome P 450 3A4/ATP-binding cassette sub-family G member 2/hydroxychloroquine分类
医药卫生引用本文复制引用
罗雪梅,姚瑶,葛卫红..细胞色素P4503A4*1G与腺苷三磷酸结合转运蛋白G超家族成员2基因多态性对羟氯喹血药浓度的影响[J].中国临床药理学杂志,2017,33(24):2572-2574,3.基金项目
南京药学会-常州四药医院药学科研基金资助项目(2015YX001) （2015YX001）
