中国临床药理学杂志2017，Vol.33Issue(24)：2575-2579,5.DOI:10.13699/j.cnki.1001-6821.2017.24.006
2013年至2015年1830株肺炎克雷伯菌感染的临床分布及耐药性分析
Distribution and antimicrobial resistance profiles of 1830 isolates of Klebsiella pneumoniae from 2013 to 2015
摘要
Abstract
Objective To investigate the distribution and antimicrobial resistance profiles of Klebsiella pneumoniae clinical isolates from the various specimens of patients at the first affiliated hospital of Wenzhou medical university and provide the evidence to prevent hospital-acquired infection using reasonably antimicrobial agents.Methods A total of 1830 Klebsiella pneumoniae isolates were isolated from various specimens of patients at the first affiliated hospital of Wenzhou medical university from January 2013 to December 2015.The distribution and antimicrobial resistance were analyzed by SPSS 19.0 software.Results Infections caused by Klebsiella pneumoniae mostly occurred in autumn and winter,and the elderly patients (≥ 46 years) were prone to suffer Klebsiella pneumoniae infections.The Klebsiella pneumoniae isolates accounted for 16.76％ of Gram-negative bacteria during investigation period.The majority of Klebsiellae pneumoniae were isolated from intensive care unites,accounting for 30.87％,and were mainly isolated from sputum.The po-sitive rates of extended spectrum beta-lactamases (ESBLs)-producing and imipenem-resistant isolates were 34.59％ and 9.84％,respectively.The resistance rates of Klebsiella pneumoniae often used antimicrobial agents were as follows:the resistance rates of ampicillin/sulbactam,ertapenem and imipenem were 41.91％,9.84％ and 9.84％,respectively.The resistance rates of the third and fourth generation cephalosporins ranged from 9.75％ to 31.58％.The resistant rates of cefoperazone/sulbactam,aztreonam,amikacin,and sulfamethoxazole were 24.32％,22.90％,9.29％ and 26.28％,respectively.Conclusion The resistance rates of Klebsiella pneumoniae to clinically often-used antimicrobial agents were high.Therefore,it is necessary to monitor the shift of antimicrobial resistance among Klebsiella pneumoniae clinical isolates.关键词
肺炎克雷伯菌/医院感染/耐药性/超广谱β内酰胺酶/碳青霉烯酶Key words
Klebsiella pneumoniae/hospital acquired infection/antimicrobial resistance/extended spectrum beta-lactamases/carbapenemases分类
医药卫生引用本文复制引用
詹玲玲,黄海霞,陈约慧,应芙蓉,余方友..2013年至2015年1830株肺炎克雷伯菌感染的临床分布及耐药性分析[J].中国临床药理学杂志,2017,33(24):2575-2579,5.基金项目
国家自然科学基金面上基金资助项目(81472011) （81472011）
温州市公益性科技计划经费资助项目(Y20170212) （Y20170212）
