中国临床药理学杂志2017，Vol.33Issue(24)：2615-2617,2641,4.DOI:10.13699/j.cnki.1001-6821.2017.24.016
姜黄素衍生物FM0807抑制佐剂性关节炎血管翳的实验研究
Inhibition of Curcumin analogue FM0807 on pannus formation in rheumatoid arthritis
摘要
Abstract
Objective To observe the inhibitory effect of Curcumin analogue FM0807 on pannus formation and its possible mechanism.Methods 40 male SD rats were used to establish the adjuvant-induced arthritis rats model,and then randomly divided into model group,control group,test A group,test B group and test C group,8 rats in each group.Another 8 healthy SD rats were used as blank control group.7 days after modeling,test A group,testB group and test C group were given 25,50,100 mg · kg-1 FM0807 through gavage ouce a day;control group was given 0.2 mg · kg-1 dexamethasone intraperitoneal injection,once a day;model group and the blank control group were given 0.9％ NaCl gavage,once a day.The rats in the six groups were treated for 21 days.Observe the content of interleukin-6 (IL-6) and tumor necrosis factor -or (TNF-α) in serum by enzyme-linked immunosorbent assay (ELISA) and determinec-Jun N-terminal kinase (JNK) protein expression by western blotting.Results The contents of TNF-α and IL-6 in serum of test A group,test B group,test C group,control group,model group and blank control group were (106.10 ± 7.15),(88.12 ± 12.75),(67.18 ±11.95),(40.96 ±9.40),(123.76 ±5.05),(18.02±10.97) pg · mL-1and (1.61 ±0.14),(1.48±0.15),(0.73 ± 0.16),(0.41 ± 0.12),(1.88 ± 0.09),(0.27 ± 0.10) pg · mL-1 respectively.JNK protein expression was (7.00 ± 1.22),(3.40 ± 0.54),(2.60 ± 0.55),(1.40 ± 0.55),(7.20 ± 1.30),(1.20 ± 0.27).The differences between test C group and model group were statistically significant (all P ＜ 0.01).Conclusion Curcumin analogue FM0807 may inhibit the formation of pannus and relieve the symptom of rheumatoid arthritis by inhibiting JNK pathway,decreasing the release of inflammatory mediators and reducing inflammatory cell stimulation.关键词
姜黄素衍生物/类风湿关节炎/血管翳/c-Jun氨基末端激酶Key words
Curcumin analogue/rheumatoid arthritis/pannus/c-Jun N-terminal kinase分类
医药卫生引用本文复制引用
张南文,檀青青,林厦珍,谢永清,聂开美,陈晓乐,吴丽贤,许建华..姜黄素衍生物FM0807抑制佐剂性关节炎血管翳的实验研究[J].中国临床药理学杂志,2017,33(24):2615-2617,2641,4.基金项目
福建省自然科学基金资助项目(2015J01318) （2015J01318）
