中国美容医学2018，Vol.27Issue(2)：91-93,3.
普奈洛尔抑制瘢痕疙瘩成纤维细胞生长机制的实验研究
Experimental Study on the Inhibitory Effect of Propranolol on the Growth of Keloid Fibroblasts
徐永飞 1武海龙 1赵哲媛 1石英光1
作者信息
- 1. 郑州大学附属洛阳中心医院烧伤美容整形外科 河南 洛阳 471000
- 折叠
摘要
Abstract
Objective To investigate the effect of propranolol on the growth mechanism of keloid fibroblasts. Methods The pathological tissues of keloid patients were selected and cultured in the medium containing propranolol (the experimental group)and simple medium (the control group).The growth curve of two groups of keloid fibroblasts was detected by CCK-8,and the absorbance values of 450-630nm was detected by Microplate reader. Results The growth ability of keloid fibroblasts in the experimental group was significantly inhibited, and the absorbance value was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion Propranolol can significantly inhibit the growth of keloid fibroblasts, and provide a new direction for the prevention and treatment of keloid in plastic surgery.关键词
瘢痕疙瘩/成纤维细胞/普萘洛尔/生长曲线Key words
keloid/fibroblasts/propranolol/growth curve分类
医药卫生引用本文复制引用
徐永飞,武海龙,赵哲媛,石英光..普奈洛尔抑制瘢痕疙瘩成纤维细胞生长机制的实验研究[J].中国美容医学,2018,27(2):91-93,3.
