中国全科医学2018，Vol.21Issue(4)：480-485,6.DOI:10.3969/j.issn.1007-9572.2018.04.023
应用鹿瓜多肽注射液治疗的颈椎病患者的临床特征与联合用药研究
Clinical Characteristics and Rules for Using Lugua Polypeptide Injection in Combination with Other Drugs among Cervical Spondylosis Patients
摘要
Abstract
Objective To investigate the clinical features and rules for using Lugua polypeptide injection in combination with other drugs among patients with cervical spondylosis. Methods From the hospital information system (HIS) of 23 tertiary grade A hospitals, we collected the in-hospital data of totaled 2 901 cervical spondylosis cases who were treated by Lugua polypeptide injection from February 2004 to November 2014. Descriptive statistical analysis of the clinical characteristics was performed. Frequency analysis and association analysis were carried out to explore the use of Lugua polypeptide injection in combination with other drugs. Results Of the 2 901 cases, 1 726 (59.5%) were 45-64 years old; top 3 complications were lumbar intervertebral disc herniation (9.6%,278/2 901), fracture (8.7%,251/2 901), and hypertension (6.0%,174/2 901); the 3 leading syndromes among 253 cases whose TCM syndromes were recorded were qi stagnation and blood stasis syndrome [136 cases (53.8%)], asthenia of liver and kidney [83 cases (32.8%)], phlegm-stasis syndrome [8 cases (3.2%)]. All of them were treated by combination use of Lugua polypeptide injection and other drugs (western/Chinese drugs). The most frequently used 3 western drugs were methylcobalamin [41.4% (1 201/2 901)], cobamamide [38.1% (1 104/2 901)] and mannitol [22.1% (642/2 901)] ,respectively;the top 3 used Chinese medicines were Jingshu granules [22.1% (642/2 901)], Jintiange capsule [18.4% (533/2 901)], Qianggu capsule [10.0% (289/2 901)], respectively; in terms of pharmacological action, the most frequently used 3 categories of western drugs were antibiotics [50.6% (1 468/2 901)], nerve nutrition drugs [45.8% (1 328/2 901)], hypertonic dehydrating agents [44.8% (1 299/2 901)], respectively; the most commonly used 3 categories of Chinese medicine were agents for promoting blood circulation to remove blood stasis [59.2%(1 716/2 901)], agents for tonifying the kidney and strengthening the bone [33.3%(967/2 901)], and those for clearing away heat and toxic materials [13.7% (397/2 901)]. Association rule analysis revealed that, of the combination of Lugua polypeptide injection + 2 types of western/Chinese medicine, Lugua polypeptide injection + Epinephrine injection +dopamine and Lugua polypeptide injection + Shengmai injection + Shenfu injection won the greatest support; the greatest support were Lugua polypeptide injection + antacid and antiulcer drug + antishock drug, and Lugua polypeptide injection + agents for clearing away heat and toxic materials + agents for promoting blood circulation to remove blood stasis. Conclusion In the management of cervical spondylosis, as the high-risk population, people aged 45-64 years should be paid special attention. For clinical treatment of this disease, Lugua polypeptide injection combined with Chinese and western medicine is most commonly used. The commonest Chinese medicines involved in the therapy are agents for promoting blood circulation to remove blood stasis, and tonifying the kidney and strengthening the bone, and the commonest western medicines are antibiotics and nerve nutrition agents.关键词
颈椎病/鹿瓜多肽注射液/医院信息系统/用药Key words
Cervical spondylosis/Lugua polypeptide injection/Hospital information system/Medication分类
医药卫生引用本文复制引用
韩涛,谢雁鸣,黎元元,张寅,庄严..应用鹿瓜多肽注射液治疗的颈椎病患者的临床特征与联合用药研究[J].中国全科医学,2018,21(4):480-485,6.基金项目
国家"重大新药创制"科技重大专项资金(2015ZX09501004-001-002) （2015ZX09501004-001-002）
北京市中医药科技发展专项资金(JJ2014-53) （JJ2014-53）
