摘要
Abstract
Objective To study the predictive value of soluble fms-like tyrosine kinase-1 (sFlt-1)/ placenta growth factor (PLGF) ratio combined with uterine artery pulsatility index (PI) for preeclampsia. Methods The enrolled participants were 382 pregnant women who underwent the conventional prenatal testing in Obstetric Clinic, The Second Affiliated Hospital of Zhengzhou University from January 2014 to January 2016, including 348 with normal pregnancy outcome (control group), 23 with mild preeclampsia (mild preeclampsia group) and 11 with severe preeclampsia (severe preeclampsia group). Clinical data of them were collected. The sFlt-1 and PLGF were measured by electro-chemiluminescence immunoassay, and the ratio of the two was calculated. Uterine artery PI was measured by three-dimensional ultrasonography. ROC curve analysis was performed to investigate the value of sFlt-1/PLGF ratio combined with uterine artery PI in the prediction of preeclampsia. Results The distribution of age, distribution of gestational weeks during sampling the peripheral venous blood for testing, gravidity, and distribution of BMI did not differ significantly between the groups (P>0.05). Both the sFlt-1/PLGF ratio and uterine artery PI varied significantly between the three groups (P<0.05), specifically, both the sFlt-1/PLGF ratio and uterine artery PI were lower in the control group compared with the preeclampsia groups (P<0.05), and they were lower in the mild preeclampsia group compared with the severe preeclampsia group (P<0.05). The sensitivity and specificity of preeclampsia incidence predicted by sFlt-1/PLGF ratio were 79.4% and 89.9%, respectively, when the critical value was 9.995, its AUC was 0.864[95%CI (0.082, 0.926)]. The sensitivity and specificity of preeclampsia incidence predicated by uterine artery PI value were 82.4% and 73.3%, respectively, when the critical value was 0.715, its AUC was 0.795[95%CI (0.700, 0.890)]. When these two markers were used in parallel combination, the sensitivity reached 97.06%, while specificity dropped to 65.80%. When used in serial combination, the sensitivity decreased to 64.71%, whereas the specificity increased to 97.41%. Conclusion sFlt-1/PLGF ratio combined with uterine artery PI has important diagnostic value for preeclampsia.关键词
先兆子痫/可溶性血管内皮生长因子受体-1/胎盘生长因子/子宫动脉搏动指数Key words
Pre-eclampsia/Soluble fms-like tyrosine kinase-1/Placenta growth factor/Uterine artery pulsatility index分类
医药卫生
