中国全科医学2018，Vol.21Issue(9)：1020-1023,4.DOI:10.3969/j.issn.1007-9572.2018.00.007
肠脑轴与帕金森病发病机制研究进展
Recent Advances in the Role of Microbiota-gut-brain Axis in the Pathogenesis of Parkinson's Disease
摘要
Abstract
Parkinson's disease (PD) is a common neurodegenerative disease. The major pathological changes of PD are abnormal aggregation of α-synuclein in the substantia nigra. However, in recent years, more and more studies have found that the enteric nervous system also has α-synuclein abnormal aggregation except the brain. The microbiota-gut-brain axis is the bidirectional communication system between the central nervous system and the gastrointestinal tract and involves neural pathways, immune and endocrine mechanisms. The enteric nervous system may spread α-synuclein through the vagus nerve to the central nervous system, so many scholars believe that PD may initially originate from the gastric-intestinal tract. In this paper, a brief review about the studies of the role of microbiota-gut-brain axis in the pathogenesis of PD in recent years will help us to explain the potential pathogenesis and some clinical features of PD. It may provide a new direction for the diagnosis and treatment of PD.关键词
帕金森病/肠神经系统/神经免疫调节/微生物-肠-脑轴Key words
Parkinson disease/Enteric nervous system/Neuroimmunomodulation/Microbiota-gut-brain axis分类
医药卫生引用本文复制引用
何屹,余刚,郑鹏,王昊天..肠脑轴与帕金森病发病机制研究进展[J].中国全科医学,2018,21(9):1020-1023,4.基金项目
重庆市科技计划项目(cstc2016jcyjA1406) （cstc2016jcyjA1406）
