中国全科医学2018，Vol.21Issue(9)：1030-1035,6.DOI:10.3969/j.issn.1007-9572.2017.00.269
MicroRNAs与心力衰竭的研究进展
Recent Advances in MicroRNAs in Heart Failure
徐曼曼 1张久亮 1范书英2
作者信息
- 1. 100029北京市,中日友好医院中西医结合心内科
- 2. 100029北京市,中日友好医院心内科
- 折叠
摘要
Abstract
MicroRNAs (miRNAs) belong to a class of evolutionarily conserved non-coding endogenous small RNAs, which can post-transcriptionally regulate gene expression via specific binding to target gene 3' untranslated region, and participate in multiple physiological and pathological processes in the body. Recently, miRNAs have been found to play an important role in myocardial fibrosis, cardiomyocyte hypertrophy as well as apoptosis. Besides, miRNAs are involved in the occurrence and development of heart failure, and can be used as a kind of new biomarkers in the diagnosis, treatment and prognosis for heart failure, thus are expected to be a new potential therapeutic target. Consequently, the recent advances in miRNAs related to heart failure was reviewed in this paper, providing a novel therapeutic method for cardiovascular disease.关键词
心力衰竭/微RNAs/生物标志物Key words
Heart failure/MicroRNAs/Biomarkers分类
医药卫生引用本文复制引用
徐曼曼,张久亮,范书英..MicroRNAs与心力衰竭的研究进展[J].中国全科医学,2018,21(9):1030-1035,6.
