中国全科医学2018，Vol.21Issue(9)：1104-1108,5.DOI:10.3969/j.issn.1007-9572.2018.00.055
柴胡疏肝散加味治疗脑卒中后焦虑障碍的临床疗效及其对心率变异性的影响
Efficacy of Modified Chaihushugan Powder and Its Impact on Heart Rate Variability among Patients with Post-stroke Anxiety Disorders
摘要
Abstract
Objective To investigate the clinical efficacy of modified Chaihushugan powder and its impact on heart rate variability (HRV) among patients with post-stroke anxiety disorders. Methods According to the inclusion and exclusion criteria of this study, we recruited 90 outpatients and inpatients with post-stroke anxiety disorders from Department of Encephalopathy, the Second Affiliated Hospital of Hunan University of Chinese Medicine from September 2015 to February 2017 and randomized them into Chinese medicine group (45 patients) receiving oral administration of citalopram hydrobromide combined with modified chaihushugan powder and the control group (45 patients) receiving oral administration of citalopram hydrobromide. Both groups were treated for 6 weeks. Comparisons were made between the groups in the aspects of total score of Hamilton Anxiety Scale (HAMA) and scores of its mental anxiety and somatic anxiety factors before treatment, at 2, 4, 6 weeks after treatment, clinical outcome after treatment, status of HRV〔time-domain indicators: SDNN (standard deviation of NN intervals calculated over a 24-hour period), SDANN (standard deviation of the average NN intervals calculated over 5 minutes within a 24-hour period), RMSSD (the root mean square of adjacent R-R interval difference within 24 hours), PNN50 (the percentage of adjacent NNR-R interval difference >50 ms within 24 hours); frequency-domain indicators: low frequency (LF), high frequency (HF), LF/HF〕 before treatment, and at 6 weeks after treatment. Results Treatment method and duration had interaction effect on HAMA total score and its two factors' scores (P<0.05); treatment duration exerted significant main effect on HAMA total score and scores of its two factors (P<0.05); treatment method produced significant main effect on HAMA total score and mental anxiety factor score (P<0.05); but did not produce significant main effect on somatic anxiety factor score (P>0.05). Chinese medicine group demonstrated much lower HAMA total score and mental anxiety factor score both at 4, 6 weeks after treatment compared with the controls (P<0.05). Compared with before treatment, HAMA total score and mental anxiety factor score decreased significantly in both groups at 2, 4, 6 weeks after treatment (P<0.05), while the somatic anxiety factor score only declined substantially in both groups at 4, 6 weeks after treatment (P<0.05). The clinical efficacy of the Chinese medicine group was better than that of the control group (P<0.05). At 6 weeks after treatment, compared with the controls, the SDNN, SDANN, PNN50 and HF were all higher (P<0.05) while LF and LF/HF were lower in the Chinese medicine group (P<0.05). Conclusion Modified Chaihushugan powder showed certain effect on post-stroke anxiety disorders as well as improved the HRV.关键词
卒中/焦虑/柴胡疏肝散/心率变异性Key words
Stroke/Anxiety/Chaihu shugan powders/Heart rate variability分类
医药卫生引用本文复制引用
张林,钟艳,全淑林,刘叶辉,石学慧,李振光,王净净..柴胡疏肝散加味治疗脑卒中后焦虑障碍的临床疗效及其对心率变异性的影响[J].中国全科医学,2018,21(9):1104-1108,5.基金项目
湖南省研究生科研创新项目(CX2016B354) （CX2016B354）
中医诊断学国家重点学科开放基金(2015ZYZD27) （2015ZYZD27）
王净净全国名老中医药专家传承工作室 （）
