中国现代医学杂志2018，Vol.28Issue(8)：13-17,5.DOI:10.3969/j.issn.1005-8982.2018.08.003
三七护肝胶囊对小鼠酒精性肝损伤的保护作用
Study on protective effect of Sanqi Hugan Capsules against alcoholic liver injury in mice
程云飞 1吕晓君2
作者信息
- 1. 湖北省仙桃市第一人民医院,湖北 仙桃 433000
- 2. 湖北省药品监督检验研究院,湖北 武汉 430075
- 折叠
摘要
Abstract
Objective To study the protective effect of Sanqi Hugan Capsules (SHC) against alcoholic liver injury in mice induced by 50% ethanol. Methods SPF-class Kunming male mice were randomly divided into 5 groups, i.e. normal control group, model control group, high-, medium- and low-dosage SHC groups with 10 in each group. After 30 days of continuous gavage, injuried liver models were made with 50% ethanol orally except the normal control group. After 16 h, the serum content of ALT and AST and the levels of MDA, SOD, GSH and TG in liver homogenate were determined, the histopathologic changes of the hepatic tissues were observed. Results The serum concentrations of ALT and AST, and the liver homogenate levels of MDA and TG in the middle-dosage and high-dosage groups were significantly decreased, and the SOD and GSH levels in the liver homogenate of the high-dosage group were significantly increased. Furthermore histopathological examination revealed fatty degeneration of the hepatic cells was significantly decreased in the high-dosage group. Conclusions SHC could protect liver against alcoholic injury.关键词
三七护肝胶囊/酒精性肝损伤/小鼠Key words
Sanqi Hugan Capsules/alcoholic liver injury/mouse分类
医药卫生引用本文复制引用
程云飞,吕晓君..三七护肝胶囊对小鼠酒精性肝损伤的保护作用[J].中国现代医学杂志,2018,28(8):13-17,5.
