中国现代医学杂志2018，Vol.28Issue(8)：39-43,5.DOI:10.3969/j.issn.1005-8982.2018.08.008
KRT19基因多态性对化疗联合靶向治疗NSCLC疗效的影响
Effect of KRT19 gene polymorphism on efficacy of chemotherapy combined with targeted therapy for non-small cell lung cancer
周小果1
作者信息
- 1. 河南省南阳市中心医院 呼吸内科,河南 南阳 473000
- 折叠
摘要
Abstract
Objective To investigate the association of the polymorphism of Cytokeratin 19 fragment (KRT19) gene with the effect of chemotherapy combined with targeted therapy for non-small cell lung cancer (NSCLC). Methods Totally 146 patients with advanced NSCLC were treated by chemotherapy combined with targeted therapy and the clinical efficacy was evaluated.Using PCR-RFLF,KRT19(-99G>C)gene was analyzed,the relationships between different genotypes of KRT19 and the efficacy of chemotherapy combined with targeted therapy were analyzed. Results The effective rate of chemotherapy with targeted therapy was significantly different between the patients with GG genotype and those with GC+CC genotype of KRT19(-99G>C)(P<0.05).The chemotherapy combined with targeted therapy was 1.897 times more sensitive in the patients carrying C genotype than that in the patients carrying T genotype[O^R=1.897(95% CI:1 103,3.647),P=0.001].MST of the KRT19(-99G>C)C allele carriers (GC+CC) was shorter than that of the GG genotype carriers (P < 0.05). Cox model analysis showed that the variant allele C of KRT19(-99G>C)was the independent risk factor for the prognosis of advanced NSCLC,OR of the variant allele carriers(GC+CC)was 2.014 times that of the GG genotype carriers(P=0.003). Conclusions KRT19 gene (-99G>C) polymorphism is the independent risk factor for the prognosis of the patients with advanced NSCLC receiving chemotherapy combined with targeted therapy, and is significantly associated with the sensitivity of chemotherapy combined with targeted therapy.关键词
非小细胞肺癌/细胞角蛋白19片段/化疗/分子靶向治疗/基因多态性Key words
non-small cell lung cancer/Cytokeratin 19 fragment/chemotherapy/molecular targeted therapy/gene polymorphism分类
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周小果..KRT19基因多态性对化疗联合靶向治疗NSCLC疗效的影响[J].中国现代医学杂志,2018,28(8):39-43,5.
