中国现代医学杂志2018，Vol.28Issue(8)：44-47,4.DOI:10.3969/j.issn.1005-8982.2018.08.009
笑气联合咪达唑仑在智障儿童口腔治疗中的应用研究
Evaluation of N2O inhalation in combination with oral Midazolam sedation in pediatric dentistry of children with intellectual disability
摘要
Abstract
Objective To evaluate the effect of N2O inhalation in combination with oral Midazolam sedation on uncooperative patients with intellectual disability in pediatric dentistry. Methods Ninety-one uncooperative pediatric patients with intellectual disability in the Outpatient Department were divided into 3 groups. The patients of the N2O group received N2O (35%-50%) inhalation conscious sedation. The patients of the Midazolam group received oral Midazolam (0.50-0.75 mg/kg) conscious sedation. The patients of the combination group received N2O inhalation and oral Midazolam conscious sedation. The heart rate, breathing rate, oxygen saturation of blood, treatment content and treatment time during oral therapy were recorded. The status of treatment was evaluated with Houpt system. All kinds of reactions within 24 hours were recorded. Treatment results and safety were statistically analyzed by Chi-square test with SPSS 17.0 software package. Results The success rates of the N2O group and the Midazolam group were 53.3% and 56.7% respectively, which were lower than 83.9% of the combination group (P < 0.05). The adverse reaction rate in the Midazolam group (33.3%) was higher than that in the combination group (6.5%) and the N2O group (6.7%). Conclusions The combination of N2O inhalation with oral Midazolam conscious sedation is effective and safe for dental treatment of uncooperative pediatric patients with intellectual disability, the incidence of adverse reactions is lower than that of Midazolam sedation alone.关键词
笑气/镇静/咪达唑仑/儿童口腔医学/智障Key words
N2O/sedation/Midazolam/pediatric dentistry/intellectual disability分类
医药卫生引用本文复制引用
游杰,胡琛,杨素媛,邵龙泉..笑气联合咪达唑仑在智障儿童口腔治疗中的应用研究[J].中国现代医学杂志,2018,28(8):44-47,4.基金项目
国家自然科学基金(No:81550011) （No:81550011）
