中国畜牧兽医2018，Vol.45Issue(2)：510-517,8.DOI:10.16431/j.cnki.1671-7236.2018.02.028
抗精神分裂症药物对吐鲁番斗鸡5-HTT和TPH1基因表达的影响
Effects of Antipsychotic Schizophrenia Drugs on the Expression of 5-HTT and TPH1 Genes in Turpan Cockfighting
摘要
Abstract
In order to investigate the molecular mechanism of different antischizophrenic drugs on the aggressive behavior of Turpan cockfighting.A total of 36 cockfightings were randomly divided into 12 groups,and four antipsychotic drugs of risperidone,aripiprazole,trazodone hydrochloride,sertraline hydrochloride were selected,and each drug was given a low dose group (L),normal dose group (N) and high dose group (H) with daily artificial oral medication.Respectively,at the 1,2,5,8,11 and 14 days,the blood samples were collected from wing vein,and the mRNA expression of 5-HTT and TPH1 genes in the blood of Turpan cockfighting at various stages of oral administration in different drugs doses were measured by quantitative Real-time PCR.The results showed that the expression change of 5-HTT and TPH1 genes mRNA in the blood of the risperidone group and aripiprazole group were similar.The overall 5-HTT gene showed a downward trend,and the TPH1 gene showed increased volatility,and the expression of TPH1 gene mRNA in risperidone group was higher than that in aripiprazole group.The expression of 5-HTT gene mRNA in the trazodone hydrochloride group and sertraline hydrochloride group increased linearly from the 5th day and peaked at the 14th day,and the TPH1 gene in the sertraline hydrochloride group was slightly up-regulated,but there was no obvious change in the trazodone hydrochloride group.It was suggested that the molecular influencing factors of the decrease in the aggressive behavior of risperidone and aripiprazole groups were related to the low expression of 5-HTT gene in the blood,and the results of this study could provide an important reference for further study on the molecular mechanism of the drug affecting the aggressive behavior of Turpan cockfighting.关键词
吐鲁番斗鸡/攻击行为/抗精神分裂症药物/5-HTT基因/TPH1基因Key words
Turpan cockfighting/aggressive behavior/antischizophrenic drugs/5-HTT gene/TPH1 gene分类
生物科学引用本文复制引用
张梅,常国斌,陈国宏,廖和荣,张苗苗,李岩,张璐,刘秀霞,李一丹,钟新献,李应生,李海英..抗精神分裂症药物对吐鲁番斗鸡5-HTT和TPH1基因表达的影响[J].中国畜牧兽医,2018,45(2):510-517,8.基金项目
国家自然科学基金项目(31360545) （31360545）
石河子大学高层次人才项目(RCZX201101) （RCZX201101）
