中国医科大学学报2017，Vol.46Issue(12)：1095-1100,6.DOI:10.12007/j.issn.0258-4646.2017.12.009
1H磁共振波谱在非小细胞肺癌脑转移放疗疗效评价中的预测价值
Predictive Value of Proton Magnetic Resonance Spectroscopy in the Evaluation of Radiotherapy for Patients with Brain Metastases from Non-small Cell Lung Cancer
摘要
Abstract
Objective To investigate the predictive value of proton magnetic resonance (MR) spectroscopy (1H-MRS) in evaluating the therapeutic efficacy of radiotherapy for patients with brain metastases from non-small cell lung cancer (NSCLC).Methods Fifty-six patients with brain metastases from NSCLC underwent 1H-MRS examination before treatment with stereotactic radiotherapy (SRT) in addition to whole brain radiotherapy (WBRT).The patients were divided into two groups according to their pretreatment choline-to-creatinine (Cho/Cr) ratio.The therapeutic efficacy of radiotherapy was compared between the two groups,and the prognostic value of 1H-MRS examination was analyzed.Results The median pretreatment Cho/Cr was 1.989.The overall survival rates at 1,3,and 5 years were 29.3％,0％,and 0％ in patients with higher pretreatment Cho/Cr,and 70.5％,22.3％,and 1.8％ in those with lower pretreatment Cho/Cr.The mean survival time was significantly lower in patients with higher pretreatment Cho/Cr than in those with lower pretreatment Cho/Cr (9.77 vs.24.67months,P ＜ 0.05).Conclusion Pretreatment Cho/Cr has a predictive value in the evaluation of radiotherapy for the treatment of NSCLC brain metastasis.Patients with higher pretreatment Cho/Cr have worse prognosis overall.关键词
1H磁共振波谱/非小细胞肺癌/脑转移/放射疗法/预后Key words
proton magnetic resonance spectroscopy/non-small cell lung cancer/brain metastasis/radiotherapy/prognosis分类
医药卫生引用本文复制引用
贺政,李光,张宏伟,张硕..1H磁共振波谱在非小细胞肺癌脑转移放疗疗效评价中的预测价值[J].中国医科大学学报,2017,46(12):1095-1100,6.基金项目
辽宁省科学技术计划(2013225021) （2013225021）
