中国肿瘤生物治疗杂志2018，Vol.25Issue(2)：137-141,5.DOI:10.3872/j.issn.1007-385x.2018.02.005
姜黄素对化学诱导大鼠肝癌缺氧模型血管生成的影响
Effect of curcumin on angiogenesis of rats with DEN-induced hepatocellular carcinoma under hypoxia
摘要
Abstract
Objective:To investigate the effect of curcumin on angiogenesis in rats with DEN (diethylnitrosamine)-induced HCC (hepatocellular carcinoma) under hypoxia.Methods:Rat HCC was induced by DEN,and its hepatic hypoxia model was established by ligating hepatic artery.The rats with established HCC model were randomly divided into four groups according to digital table method:lipiodol embolization group (group A),lipiodol combined with curcumin embolization group (group B),lipiodol combined with peripheral liver capsule group (group C),lipiodol combined with curcumin and peripheral liver capsule group (group D),with 10 rats in each group.VEGF expression in HCC cells and tissues,microvessel density (MVD),and median survival time (MST) of rats in each group were compared.Results:VEGF protein expression and microvessel density in group B,D were significantly lower than those in A group (P＜0.01),while those in C group had no significant difference compared with group A (P＞0.05).MST in group B,C and D was significantly longer than that in group A (P＜0.05),and the MST in group D was higher than that in group B and C (P＜0.05).Conclusion:Curcumin can inhibit tumor angiogenesis and decrease VEGF expression and MVD in HCC rats under hypoxia,thus further prolong the survival time of the rats.关键词
姜黄素/大鼠/肝细胞癌/缺氧/血管生成Key words
curcumin/rat/hepatocellular carcinoma/hypoxia/angiogenesis分类
医药卫生引用本文复制引用
杨传玉,曾荣耀,刘荣亮,王小文,柯恩明,刘静..姜黄素对化学诱导大鼠肝癌缺氧模型血管生成的影响[J].中国肿瘤生物治疗杂志,2018,25(2):137-141,5.基金项目
福建省自然科学基金资助项目(No.2017J01164) （No.2017J01164）
漳州市科技拥军项目(No.ZZ2016KD06) （No.ZZ2016KD06）
南京军区医学科技创新项目(No.11MA082). Project supported by the Natural Science Foundation of Fujian Province (No.2017J01164),the Science and Technology Supporting Army Program of Zhangzhou City (No.ZZ2016KD06),and the Medical Science and Technology Innovation of Nanjing Military Region (No.11MA082) （No.11MA082）
