中国肿瘤生物治疗杂志2018，Vol.25Issue(2)：170-176,7.DOI:10.3872/j.issn.1007-385x.2018.02.011
PD-1/PD-L1在胃癌组织中的表达及其临床意义
Expression and clinical significance of PD-1/PD-L1 in gastric cancer tissues
摘要
Abstract
Objective:To investigate the expression and clinical significance of PD-1/PD-L1 in gastric cancer (GC) tissues.Methods:Paraffin embedded tumor tissues and clinical data of 82 GC patients who had undergone operation at the Fourth Hospital of Hebei Medical University from January 2007 to December 2007 were collected,and their survival status was followed.The protein expressions of PD-1 and PD-L1 in tumor tissues were detected by immunohistochemistry.Kaplan-Meier analysis and Log-Rank test were adopted to analyze the survival of GC patients,and the ROC curve was plotted.Results:The positive rate of PD-L1 protein expression was 42.68％ while the positive rate of PD-1 expression was 13.41％ in GC tissues.The positive rate of PD-1 and PD-L1 expression in GC tissues of patients without pre-operative distant metastasis was significantly lower than those patients with pre-operative metastasis (PD-1:3.28％ vs 42.86％;PD-L1:13.11％ vs 90.48％;all P＜0.01).The positive rate of PD-L1 expression in tumor stroma of patients without pre-operative distant metastasis was significantly lower than those with metastasis (PD-L1:13.11％ vs 47.62％,P＜0.01).The resection range of stomach,PD-L1 over-expression and the presence of pre-operative distant metastasis were the adverse factors affecting the prognosis of patients with GC (P＜0.05).Conclusion:PD-1 and PD-L1 expressions in GC tissues were closely related to the presence of pre-operative distant metastasis and the depth of tumor infiltration.The postoperative survival of patients who were PD-L1 positive was shorter than the negative ones.关键词
胃癌/PD-1/PD-L1/免疫治疗/预后/免疫检查点抑制剂Key words
gastric cancer(GC)/PD-1/PD-L1/immunotherapy/prognosis/checkpoint inhibitor分类
医药卫生引用本文复制引用
张风宾,乔静雪,王英南,赵飞,张韶辰,张瑞星..PD-1/PD-L1在胃癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2018,25(2):170-176,7.基金项目
河北省自然基金课题资助项目(No.H2015206461).Project supported by Natural Science Foundation of Hebei Province (No.H2015206461) （No.H2015206461）
