中成药2018，Vol.40Issue(2)：265-270,6.DOI:10.3969/j.issn.1001-1528.2018.02.004
糖脂康平颗粒对糖脂代谢紊乱大鼠血糖血脂的作用
Effects of Tangzhi Kangping Granules on the blood sugar and lipid in rats with disordered glucose and lipid metabolism
摘要
Abstract
AIM To observe the effects of Tangzhi Kangping Granules (Astragali Radix,Ligustri lucidi Fructus,Schisandrae chinensis Fructus,etc.) on regulating blood sugar and lipid of rats with glucose and lipid metabolism disorders.METHODS Among the seventy rats for the trial,ten rats were randomly assigned to normal control group,the other 60 rats were injected with STZ citric acid-sodium citrate solution (60 mg/kg) combined with high-fat emulsion (10 mL/kg) for 4 weeks to be the models of glucose and lipid metabolism disorders.The model rats were divided into model control group,mefformin + fenofibrate group,Xiaoke Pills + Xuezhikang group,and high,medium and low dose Tangzhi Kangping Granules groups.After 4-week intragastric administration,the rats had their levels of fasting serum glucose (GLU),triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipids (LDL-C),insulin (INS),adiponectin (ADP),leptin (Leptin),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) measured.RESULTS Compared with the model control group,the rats in high,medium and low dose Tangzhi Kangping Granules groups displayed significantly decreased serum contents of GLU,TG and TC,lowered levels of LDL-C,ADP,Leptin,IL-6,TNF-α,and yet significantly increased levels of HDL-C and INS.CONCLUSION Tangzhi Kangping Granules,a blood sugar andlipid regulator may adjust the levels of insulin,adiponectin and leptin,and therefore improves the body's inflammatory environment to alleviate insulin resistance.关键词
糖脂康平颗粒/糖尿病/高脂血症Key words
Tangzhi Kangping Granules/diabetes/hyperlipidemia分类
医药卫生引用本文复制引用
刘媛,李茹月,陈玉兴,黄雪君,曾晓会,黄丹娥,甘海宁,唐洪梅..糖脂康平颗粒对糖脂代谢紊乱大鼠血糖血脂的作用[J].中成药,2018,40(2):265-270,6.基金项目
广东省科技计划项目(2013B060300034,2014A070705014,2015A040404030) （2013B060300034,2014A070705014,2015A040404030）
广东省中医药局重点项目(20173002) （20173002）
