中成药2018，Vol.40Issue(2)：294-299,6.DOI:10.3969/j.issn.1001-1528.2018.02.009
银杏内酯B对急性心肌梗死患者血运重建后心室壁运动的影响
Effects of ginkgolide B on the ventricular wall motion of patients with acute myocardial infarction after revascularization
江家华 1邓庆华 1高于英1
作者信息
- 1. 云南省中西医结合医院,云南昆明650051
- 折叠
摘要
Abstract
AIM To investigate the role of ginkgolide B on the ventricular wall motion and systolic function in acute myocardial infarction (AMI) patients after their revascularization.METHODS A total of 80 cases of AMI patients who underwent revascularization were divided into control group and ginkgolide B treatment group,with 40 patients per group.The two groups of patients both treated basically with routine western medicine were dosed with either placebo or ginkgolide B for 3 months.The cardiac function,normal myocardial percentages,ventricular wall motion,longitudinal peak systolic strain (LPSS) and rate (LPSSR) were evaluated by dobutamine stress echocardiography and these indexes were compared.RESULTS Compared to the control group,left ventricular ejection fraction (LVEF) (66.06 ± 8.39 vs.60.45 ± 13.35,P ＜0.05) and normal myocardial percentages (86.88 ±8.76 vs.79.84 ± 12.25,P ＜0.01) were significantly improved at the 2nd week in ginkgolide B treatment group,but no significant difference on ventricular wall motion was observed'between the two groups (P ＞ 0.05).For the patients with anterior wall AMI,the minus LPSS and LPSSR at basal,middle and apex segment were significantly improved at the 2nd week in ginkgolide B treatment group compared to the control group (P ＜ 0.05,P ＜ 0.01).Moreover,LPSS at apex segment was significantly improved at the 3rd month in ginkgolide B treatment group compared to the control group (P ＜ 0.05).For the patients with inferior wall AMI,minus LPSS at basal and apex segment were significantly improved at the 2nd week and the 3rd month in ginkgolide B treatment group compared to the control group (P ＜ 0.05),whereas minus LPSSR at basal and middle segment at the 2 nd week and basal segment at the 3rd month were significantly improved in ginkgolide B treatment group compared to the control group (P ＜0.05).CONCLUSION Revascularized AMI patients treated with ginkgolide B can expect an improved ventricular wall motion.关键词
银杏内酯B/急性心梗/血运重建/心室壁运动Key words
ginkgolide B/acute myocardial infarction (AMI)/revascularization/ventricular wall motion分类
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江家华,邓庆华,高于英..银杏内酯B对急性心肌梗死患者血运重建后心室壁运动的影响[J].中成药,2018,40(2):294-299,6.
