中成药2018，Vol.40Issue(2)：320-325,6.DOI:10.3969/j.issn.1001-1528.2018.02.014
姜黄提取物二氧化硅固体分散体的制备与表征
Preparation and characterization of SiO2 solid dispersions of Curcumae longae Rhizoma extract
摘要
Abstract
AIM To prepare and characterize SiO2 solid dispersions of Curcumae longae Rhizoma extract.METHODS For the solid dispersions prepared by solvent evaporation method,its ratio of extract to carrier (SiO2) was screened by in vitro dissolution test,and the characterization was achieved by determination of particle size,specific surface area,porosity,micromorphology observation,infrared spectroscopy and X-ray.RESULTS When the ratio of extract to carfer was 1:8,three main components (bisdemethoxycurcumin,demethoxycurcumin and curcumin) in the extract reached the highest accumulative dissolution rates.Compared with physical mixture,the solid dispersions demonstrated lower particle size,specific surface area and porosity.Extract was dispensed in the carrier in an amorphous state.CONCLUSION SiO2 solid dispersions can obviously improve the dissolution rates of the main components in Curcumae longae Rhizoma extract.关键词
姜黄提取物/二氧化硅固体分散体/制备/表征/溶剂蒸发法/体外溶出试验Key words
Curcumae longae Rhizoma extract/SiO2 solid dispersions/preparation/characterization/solvent evaporation method/in vitro dissolution test分类
医药卫生引用本文复制引用
姜红,张定堃,柯秀梅,许润春,林俊芝,韩丽,李红彦..姜黄提取物二氧化硅固体分散体的制备与表征[J].中成药,2018,40(2):320-325,6.基金项目
国家自然科学基金资助项目(8127409881773918) （8127409881773918）
国家基础科学人才培养基金(J13100340-19) （J13100340-19）
