中药材2017，Vol.40Issue(9)：2138-2140,3.DOI:10.13863/j.issn1001-4454.2017.09.032
基于分子印迹技术的左旋延胡索乙素微球的制备及体外释药研究
Preparation and Release Studies of L-Tetrahydropalmatine Microspheres Based on Molecular Imprinting Technique
摘要
Abstract
Objective:To prepare the sustained release microspheres of L-tetrahydropalmatine(L-THP)by the molecular imprinting technique.Methods:L-THP was used as template,methyl acrylic acid (MAA)was used as functional monmer,ehtylene glycol dimethacrylate(EDMA) was used as a cross-linking agent to prepare the sustained release microspheres.L-THP microspheres was prepared by precipitation polymerization,and a test was conducted to investigate the performance of adsorption and drug controlled release in artificial gastric juice.Results:The experiment showed that the sustained release microspheres had specific adsorption to L-THP,the adsorption capacity was up to 1.97 μmol/g,the molecular imprinted polymers(MIPs) microspheres had obvious drug release capacity in artificial gastric juice in 5 h.Conclusion:The sustained release microspheres have a good adsorption and drug controlled release performance of L-THP.关键词
分子印迹技术/微球/左旋延胡索乙素/分子印迹聚合物Key words
Molecular imprinting technique/Microspheres/L-tetrahydropalmatine/Molecular imprinted polymers分类
医药卫生引用本文复制引用
李博,朱俊访,聂阳..基于分子印迹技术的左旋延胡索乙素微球的制备及体外释药研究[J].中药材,2017,40(9):2138-2140,3.基金项目
广东省医学科学技术研究基金项目(A2015470) （A2015470）
广东省中医药局科研项目(20162027) （20162027）
