中药材2017，Vol.40Issue(9)：2172-2176,5.DOI:10.13863/j.issn1001-4454.2017.09.039
鸡血藤水提物抗抑郁作用研究
Antidepressive-like Effect of Aqueous Extract from Spatholobus suberectus
摘要
Abstract
Objective:To investigate the antidepressive-like effect of aqueous extract from Spatholobus suberectus,and to study its related mechanism.Methods:The classical mice tail suspension test and mice force swimming test were used to evaluate the antidepressive-like effect of aqueous extract from Spatholobus suberectus.Female rat climacteric depression model was copied using the method of ovariectomy combined with chronic unpredictable mild stimulation(CUMS).The antidepressive-like mechanism of aqueous extract from Spatholobus suberectus was investigated from the view of nerve inflammation.Results:Aqueous extract from Spatholobus suberectus significantly decreased immobility time in tail suspension test and force swimming test in the doses of 8,4,and 2 g/kg(P＜0.05 or P＜0.01).However,it had no effects on autonomic activities.In depression rats experiment,aqueous extract of Spatholobus suberectus in the dose of 4 g/kg significant decreased immobility time of depression rats in force swimming test (P＜0.05).Aqueous extract from Spatholobus suberectus in the dose of 4,1 g/kg can significantly decreased the levels of TNF-α and IL-1β in hippocampus tissue of depression rats(P＜ 0.01),while it has no obvious effects in cerebral cortex (P＞0.05).Immunohistochemical results showed that the expression of NF-κBp65 in cerebral cortex and hippocampus tissue of depression rats were significantly decreased in the dose of 4,1 g/kg of aqueous extract of Spatholobus suberectus.Conclusion:Aqueous extract from Spatholobus suberectus has definitely anti depressive effect.The mechanism may be related to the inhibition of nerve inflammation.关键词
鸡血藤水提物/抗抑郁/神经炎症/NF-κBp65Key words
Aqueous extract of Spatholobus suberectus Dunn/Antidepressive-like/Nerve inflammation/NF-κBp65分类
医药卫生引用本文复制引用
曹斌,李冬梅,韦桂宁,苏启表,苏华,何飞,农志欢..鸡血藤水提物抗抑郁作用研究[J].中药材,2017,40(9):2172-2176,5.基金项目
国家自然科学基金(81360653,81560663) （81360653,81560663）
广东省中医药局建设中医药强省项目(20151270) （20151270）
广西中药质量标准研究重点实验室青年骨干创新基金(201606,201608) （201606,201608）
