安徽农业科学2018，Vol.46Issue(9)：141-142,160,3.
黄鲫蛋白抗菌肽-纳米氧化锌络合物对小鼠肠黏膜氧化性的影响
Effects of the Nanocomposite of Half-fin Anchovy Antibacterial Peptides and Zinc Oxide Nanoparticles on Oxidative Status of Intesti-nal Mucosa in Mice
摘要
Abstract
[Objective]To study the effect of the antibacterial peptide-nanoscale Zinc Oxide complex on the intestinal mucosal oxidation of the crucian carp. [Method]Mice were used as animal models,the effects of the nanocomposite of half-fin anchovy antibacterial peptides and zinc oxide nanoparticles on the oxidative status of intestinal mucosa were investigated in mice model. Results of transmission electron microscope a-nalysis showed that the microstructure of the nanocomposite of half-fin anchovy antibacterial peptides and zinc oxide nanoparticles was irregular polymer. This nanocomposite was injected into mice jejunum and adsorbed for 30 min,then the activities of myeloperoxidase(MPO) and glu-tathione peroxidase(GPx) were determined,as well as the contents of LPO and MDA were measured.[Result]Results showed a significant in-crease of MPO and decrease of GPx for jejunum mucosa. The content of LPO was dramatically decreased. In contrast,the content of MDA was significantly increased. [Conclusion]This study showed that yellow carp protein nano antibacterial peptide-Zinc Oxide complex can change the intestinal mucosal key enzymes MPO and GPx activity,but the sensitivity of different enzymes,increased the activity of MPO and LPO may de-crease the content related,while GPx activity decreased resulted in the increase of MDA content.关键词
黄鲫蛋白抗菌肽/纳米氧化锌/聚合物/微观特征/肠黏膜/氧化性Key words
Half-fin anchovy antibacterial peptides/Zinc oxide nanoparticles/Polymer/Microstructure property/Intestinal mucosa/Oxidative status分类
轻工纺织引用本文复制引用
谷盈睿,韦荣编,宋茹..黄鲫蛋白抗菌肽-纳米氧化锌络合物对小鼠肠黏膜氧化性的影响[J].安徽农业科学,2018,46(9):141-142,160,3.基金项目
浙江省公益技术研究农业项目(2016C32066) （2016C32066）
浙江省自然科学基金一般项目(LY15C200018). （LY15C200018）
