吉林大学学报（医学版）2018，Vol.44Issue(2)：346-349,后插4,5.DOI:10.13481/j.1671-587x.20180225
妊娠高血压综合征患者胎盘组织中HIF-1α和HSP70的表达及其意义
Expressions of HIF-1α and HSP70 in placenta tissue of patients with pregnancy-induced hypertension syndrome and their significances
摘要
Abstract
Objective:To investigate the expressions of hypoxia-inducible factor-1α(HIF-1α)and heat shock protein 70(HSP70)in the placenta tissue of the patients with pregnancy-induced hypertension syndrome(PIH), and to elucidate the clinical significances of their expressions in the placenta tissue of the patients with PIH. Methods:Twenty-two cases of placenta tissue of the PIH patients(PIH group)and eighteen cases of placenta tissue of the normal pregnant women(control group)were selected.The expressions of HIF-1αand HSP70 were detected by immunohistochemical method.The differences of potive expressions rates of HIF-1α and HSP70 in placenta tissue of the PIH patients and the normal pregnant women and their relationships in placenta tissue of the PIH patients were analyzed.Results:The positive expression rate of HIF-1α in placenta tissue of the patients in PIH group(81.8%)was higher than that of the normal pregnant women in control group(38.9%)(χ2=7.785,P=0.005),and the positive expression rate of HSP70 in placenta tissue of the patients in PIH group(90.9%)was higher than that of the normal pregnant women in control group(55.6%)(χ2=6.599,P=0.010).Eighteen cases of placenta tissue with HIF-1α positive expression in the PIH patients had HSP70 positive expression(100.0%);among four cases of placenta tissue with HIF-1α negative expression,two cases had HSP70 negative expression (50.0%);their expressions in placenta tissue of the PIH patients had positive correlation(r=0.671,P=0.001). Conclusion:The expressions of HIF-1αand HSP70 in placenta tissue of the PIH patients are higher,and they have positive correlation.关键词
妊娠高血压综合征/胎盘组织/缺氧诱导因子1α/热休克蛋白70/相关性分析Key words
pregnancy-induced hypertension syndrome/placenta tissue/hypoxia-inducible factor-1α/heat shock protein 70/correlation analysis分类
医药卫生引用本文复制引用
蓝永洪,饶朗毓,杨智,黄明媚,牛海艳,齐亚灵..妊娠高血压综合征患者胎盘组织中HIF-1α和HSP70的表达及其意义[J].吉林大学学报（医学版）,2018,44(2):346-349,后插4,5.基金项目
海南省科技厅自然科学基金资助课题(814301) （814301）
