重庆医学2018，Vol.47Issue(8)：1052-1054,3.DOI:10.3969/j.issn.1671-8348.2018.08.013
云南地区汉族人群CYP2C9和VKORC1基因多态性研究
Genetic polymorphisms of CYP2C9 and VKORC1 among Han population in Yunnan area
摘要
Abstract
Objective To understand the frequency distribution of CYP2C9 and VKORC1 gene single nucleotide polymor-phisms in Yunnan Han population.Methods CYP2C9(430C> T,1075A>C and 1080C> G)locus and VKORC1(-1639G> A and 1173C> T)locus gene polymorphisms in 202 samples were detected by adopting electrochemical gene sensor method,and the allele frequencies and genotype frequencies were performed the statistics and the gene polymorphism in relevant populations was an-alyzed.Results Among 202 samples,202 cases(100.0%)were genotype C/C at CYP2C9 * 2 locus,C allele frequency was 100.0%;185 cases(91.6%)were genotype A/A at CYP2C9*3 locus,15 cases(7.4%)were A/C genotype,2 cases(1.0%)were C/C genotype,A allele frequency was 95.3%,C allele frequency was 4.7%;CYP2C9*5 locus genotype C/C was in 202 cases (100.0%),C allele frequency was 100%;VKORC1 -1639G > A locus genotype A/A was in 145 cases(71.8%),57 cases (28.2%)were G/A genotype,A allele frequency was 85.9%,G was 14.1%;1173C> T locus genotype T/T was in 145 cases (71.8%),C/T gene type in 57 cases(28.2%),T allele frequency was 85.9%,and C was 14.1%.Conclusion The distribution of CYP2C9 gene in Yunnan Han population is similar to that in other regions of our country.The VKORC1 gene is different from the foreign population,Chinese Han nationality and partial minority nationalities.关键词
云南/汉族/CYP2C9/VKORC1/基因多态性Key words
Yunnan/Han nationality/CYP2C9/VKORC1/gene polymorphism分类
医药卫生引用本文复制引用
赵晓丽,史琼华,黄宏伟,钱净,邵剑春,黎海生,杨悦林,陈俊,胡大春..云南地区汉族人群CYP2C9和VKORC1基因多态性研究[J].重庆医学,2018,47(8):1052-1054,3.基金项目
昆明市科技计划项目(2016-1-S-06350). （2016-1-S-06350）
