动物营养学报2018，Vol.30Issue(1)：59-65,7.DOI:10.3969/j.issn.1006-267x.2018.01.009
脂多糖引起炎症反应的表观遗传学机制及其营养调控
Epigenetic Mechanisms of Lipopolysaccharide-Induced Inflammation and Their Nutritional Manipulations
摘要
Abstract
In practical animal production,lipopolysaccharide widely exists in air,drinking water,feed and fe-ces. In addition, heat stress and the feeding of high concentrate diets also lead to release of more lipopolysac-charide in digestive tract. When lipopolysaccharide enters the body,it can cause inflammation. Studying molec-ular mechanisms and manipulative avenues of lipopolysaccharide-induced inflammation is of great significance for improving animal health and production performance. From an epigenetic point of view,mechanisms of in-flammation may be better understood at the molecular level. Moreover,there is a close relationship between nu-tritional factors and epigenetic alterations. This article reviewed the epigenetic mechanisms of lipopolysaccha-ride-induced inflammation and their nutritional manipulations.关键词
脂多糖/炎症反应/表观遗传/机制/营养调控Key words
lipopolysaccharide/inflammation/epigenetics/mechanism/nutritional manipulation分类
农业科技引用本文复制引用
陈静波,董国忠,孙雅望,张翥..脂多糖引起炎症反应的表观遗传学机制及其营养调控[J].动物营养学报,2018,30(1):59-65,7.基金项目
国家自然科学基金面上项目(31672448) （31672448）
重庆市科委社会民生科技创新专项(cstc2016shmszx80078) （cstc2016shmszx80078）
