口腔疾病防治2018，Vol.26Issue(3)：143-150,8.DOI:10.12016/j.issn.2096-1456.2018.03.002
口腔扁平苔藓治疗现状分析
The present situation in treatment for oral lichen planus
摘要
Abstract
Oral lichen planus (OLP), a common and chronic disorder, has no effective treatment or cure because its etiology is complicated and has until now remained unclear. Therefore, effectively controlling the activity of the disease and preventing its recurrence are two primary purposes of clinical treatment for OLP. The available evidence supports the notion that topical steroids are the preferred drug for treating this disease. However, some cases have poor clinical curative responses to steroids or other medicines, mainly because of drug resistance and other factors. Therefore, schol-ars have explored new drugs and methods with the aim of achieving more effective and safe treatment effects. The cur-rent research evidence indicates that glucocorticoid remains the front-line drug for OLP treatment. Topical tacrolimus, pimecrolimus and retinoic acid combined with glucocorticoid can be used as alternative therapies, especially in cases with glucocorticoid drug resistance. The systemic application of glucocorticoid or immunosuppressive agents, such as methotrexate, mycophenolate mofetil, and sulfoxide, should be limited to extensive, refractory cases or those with lesions involving regions outside the oral cavity. Surgery and cryotherapy can be applied in a specific, limited range of lesions. Some previous randomized controlled clinical studies have had limitations, including a small sample size, short treat-ment and clinical follow-up periods, a lack of reliable questionnaires and differences in evaluation standards. Therefore, future studies should include the following:randomized controlled clinical studies with large sample sizes that offer reli-able evidence of a curative effect;assessments of treatment outcomes should be extended as long as possible;the follow-up period should be long enough to assess the recurrence rate; and the methods and standards used to evaluate treat-ment effects should be standardized.关键词
口腔扁平苔藓/药物治疗/糖皮质激素/他克莫司/免疫抑制剂/手术治疗/冷冻治疗/光动力治疗Key words
Oral lichen planus/Medication/Glucocorticoid/Tacrolimus/Immunosuppressive agents/Sur-gical treatment/Cryotherapy/Photodynamic therapy分类
医药卫生引用本文复制引用
陶小安,程斌..口腔扁平苔藓治疗现状分析[J].口腔疾病防治,2018,26(3):143-150,8.基金项目
国家自然科学基金项目(81771070) （81771070）
广州市科技计划项目(201607010347) （201607010347）
