广东药科大学学报2018，Vol.34Issue(1)：39-44,6.DOI:10.16809/j.cnki.2096-3653.2017121101
N-杂环卡宾钯配合物高效催化杂环类铃木偶联反应的研究
The highly efficient Suzuki-Miyaura cross-coupling of heterocycles by Pd-NHCs
摘要
Abstract
Objective To synthesize heterocyclic products with Suzuki-Miyaura cross-coupling reactions catalyzed by N-heterocyclic carbene palladium complexes. Methods A N-heterocyclic carbene palladium complex was synthesized as an efficient catalyst for the coupling reaction of aryl boronic acids and aryl chlorides. The conditions were optimzed via the change of catalyst loading,solvent with different polarity and base with different intensity. Results A N-heterocyclic carbene palladium complexes was synthesized. The optimal cross-coupling conditions were as follows,EtOH as solvent,K2CO3as base,reaction for 4 h in the air at 80℃. The cross-coupling products,up to 18 examples,with yields up to 90%,were obtained and characterized by 1H NMR and 13C NMR. Conclusion The N-heterocyclic carbene palladium complexes exhibited high catalytic efficiency for the Suzuki-Miyaura reactions, which could be used to synthesize a variety of heterocyclics under mild conditions and suitable for chlorinated heterocyclic substrates.关键词
N-杂环卡宾钯配合物/铃木偶联反应/杂环化合物/氯代杂环底物Key words
N-heterocyclic carbene/Suzuki-Miyaura/heterocyclic compounds/chlorinated heterocyclic substrates分类
医药卫生引用本文复制引用
陆冬冬,胡立群,刘丰收,蒋艳云,张飞意,申东升..N-杂环卡宾钯配合物高效催化杂环类铃木偶联反应的研究[J].广东药科大学学报,2018,34(1):39-44,6.基金项目
广东省自然科学基金项目(51361061) （51361061）
