广东药科大学学报2018，Vol.34Issue(1)：59-63,5.DOI:10.16809/j.cnki.2096-3653.2017112001
七叶皂苷钠对急性肺损伤大鼠肺纤维化的干预作用
The intervening effect of sodium aescinate on pulmonary fibrosis in ALI rats
摘要
Abstract
Objective To explore the intervening effect of sodium aescinate on pulmonary fibrosis in ALI rats.Methods The rats were randomly divided into the normal group,the model group and sodium aescinate group. The rat model of acute lung injury was induced by administration of oleic acid. Sodium aescinate group rats were intravenously injected of sodium aescinate for 14 days. The 11 rats were sacrificed at 1st and 14th day after last administration. The indexs of weight,arterial partial pressure of oxygen (PaO2), oxygenation index (PaO2/FiO2),lung index and wet/dry ratio,IL-1β,TNF-α,PCⅢ,TGF-β1 and the lung histopathology in rats were observed.Results Compared with the model group,there was no difference in rat weight,lung index and wet/dry ratio. After treatment with sodium aescinate,the levels of PaO2and PaO2/FiO2were increased. Meantime,the levels of IL-1β,TNF-α,PCⅢ,TGF-β1 and IQA were reduced,and the lung histopathology damage was lighten. Conclusion Sodium aescinate can reduce the levels of inflammatory factors,which shows a preventive effect on pulmonary fibrosis to ALI rats.关键词
七叶皂苷钠/急性肺损伤/炎症因子/纤维化/干预作用Key words
sodium aescinate/ALI/inflammatory factors/fibrosis/intervening effect分类
医药卫生引用本文复制引用
黄桑,蒙凌,王志远,林涛,曾昭智..七叶皂苷钠对急性肺损伤大鼠肺纤维化的干预作用[J].广东药科大学学报,2018,34(1):59-63,5.基金项目
广东省中医药局科研项目(20172093) （20172093）
