中国妇幼健康研究2018，Vol.29Issue(3)：276-280,5.DOI:10.3969/j.issn.1673-5293.2018.03.008
盐城市空气污染物对手足口病发生风险的影响研究
Influence of air pollutants on occurrence risk of hand-foot-mouth disease in Yancheng City
摘要
Abstract
Objective To explore the influence of particulate matter(PM10),sulfur dioxide(SO2)and nitrogen dioxide(NO2)on the occurrence risk of hand-foot-mouth disease(HFMD)in every district and county of Yancheng City.Methods Incidence data of HFMD in 9 districts and counties of Yancheng during 2005—2015 as well as data of air pollutant concentrations and meteorological conditions in corresponding period were collected.Generalized additive model(GAM)was used to explore the relationship between occurrence of HFMD and air pollutants(PM10,SO2and NO2)of different lag days in different time of each district and county, after adjusting effects of meteorological factors,long-term trend and"day of week".Finally,meta-analysis was performed on results of these 9 districts and counties to further obtain comprehensive effects.Results Spearman correlation analysis showed that there was a positive correlation between any two of PM 10,SO2and NO2(r>0,P<0.05)in 9 districts and counties.As a whole, the three pollutants were negatively correlated with mean temperature and relative humidity(r<0,P<0.05).Results of GAM and meta-analysis indicated that when lagging for 2 days,an increase of 10μg/m3in daily mean concentration of PM 10,SO2and NO2could increase the occurrence risk of HFMD by 0.38%(95% CI:0.03% —0.73%),1.98%(95% CI:0.34% —3.65%)and 1.59%(95% CI:0.53% —2.66%),respectively.Meanwhile,the results of multi-pollutant model showed that when one or more pollutants were introduced to the model,differences in the influence of NO2on the occurrence of HFMD were always statistically significant(Double-pollutant model:Adjusting PM10:Z=2.73,P=0.06;Adjusting SO2:Z=2.84,P=0.004;Three-pollutant model:Z= 2.64,P = 0.08).Conclusion Air pollutants(PM10,SO2and NO2)in Yancheng City may lead to an increase of occurrence risk of HFMD.Therefore,detection of these pollutants should be strengthened to reduce the incidence of HFMD.关键词
手足口病/广义相加模型/空气污染物可吸入颗粒物/二氧化硫/二氧化氮Key words
hand-foot-mouth disease(HFMD)/generalized additive model(GAM)/particulate matter 10(PM10)/sulfur dioxide (SO2)/nitrogen dioxide(NO2)分类
医药卫生引用本文复制引用
卢小敏,储海燕,吴冬梅,孙中友..盐城市空气污染物对手足口病发生风险的影响研究[J].中国妇幼健康研究,2018,29(3):276-280,5.基金项目
江苏高校品牌专业建设工程资助项目(项目编号:PPZY2015A067) （项目编号:PPZY2015A067）
江苏省高校自然科学研究面上资助项目(15KJB330002) （15KJB330002）
江苏高校优势学科建设工程资助项目 （）
