中国妇幼健康研究2018，Vol.29Issue(3)：281-283,3.DOI:10.3969/j.issn.1673-5293.2018.03.009
PON2与LT在儿童睡眠呼吸暂停综合征中的变化分析
Changes of PON2 and LT in children with obstructive sleep apnea syndrome
摘要
Abstract
Objective To investigate the correlation and clinical biological significance of expression levels of paraoxonase 2(PON2) and leukotriene(LT)in children with obstructive sleep apnea syndrome(OSAS)and to provide molecular pathological basis for exploring the injury mechanism of cell hypoxia metabolic in OSAS.Methods Thirty-two children newly diagnosed with OSAS and untreated in Xi'an Children's Hospital from February 2015 to June 2016 and 18 normal children undergoing physical check at the same time were selected.Normal children were set as controls.Differences in PON2 and LT during sleeping and waking period were compared in OSAS children.Results There were significant differences in expressions of PON2 and LT among normal children and children with light,moderate and severe OSAS(sleeping)and children with OSAS(waking)(t value was 1.56,1.60,1.45, 1.41,1.58 and 1.60,respectively,all P< 0.05).No significant differences in expression levels of PON 2 and LT were found between OSAS children(sleeping)and OSAS children(waking)(t value was 1.79 and 1.81,respectively,both P> 0.05). Spearman correlation analysis showed that expression levels of PON 2 and LT were positively correlated with grade of apnea —hypopnea index(AHI)and r value was 0.78 and 0.66,respectively(both P<0.05).Conclusion PON2 and LT are correlated with grade of AHI in OSAS children,which can be regarded as independent factor for diagnosis and grading of OSAS.关键词
对氧磷酶2/白三烯/儿童睡眠呼吸暂停综合征/生物节律Key words
paraoxonase2(PON2)/leukotriene(LT)/obstructive sleep apnea syndrome(OSAS)/biorhythm分类
医药卫生引用本文复制引用
程玮,张雯,闫堃..PON2与LT在儿童睡眠呼吸暂停综合征中的变化分析[J].中国妇幼健康研究,2018,29(3):281-283,3.基金项目
陕西省社会发展攻关项目资助(2011K13—03—11) （2011K13—03—11）
