解放军医药杂志2018，Vol.30Issue(2)：1-4,4.DOI:10.3969/j.issn.2095-140X.2018.02.001
表皮生长因子受体组织基因突变状态与自体细胞免疫联合序贯化放疗治疗肺癌骨转移效果的关系分析
Effect Analysis of EGFR Gene Mutation and Autologous CIK Cell Immunotherapy Combined with Sequential Radiotherapy in Treatment of Lung Cancer Associated by Bone Metastasis
摘要
Abstract
Objective To analyze correlation between epidermal growth factor receptor (EGFR) gene mutation and autologous cytokine-induced killer (CIK) cell immunotherapy combined with sequential radiotherapy in treatment of lung cancer associated by bone metastasis. Methods A total of 91 patients with lung cancer associated by bone metastasisadmitted during January 2015 and May 2017 underwent CIK cell immunotherapy combined with autologous sequential chemo radiotherapy, and the patients were divided into effective group and ineffective group according to treatmentresults. Differences of EGFR mutations were detected by immunohistochemistry and gene sequencing, and the correlation between difference of EGFR mutations and curative effect was analyzed. Results Immunohistochemistry and gene sequencing detection results showed that mutation detection score and positive rate of del19 and mut21 in effective group were higher than those in ineffective group (P <0. 05). Conclusion Autologous CIK cell immunotherapy combined with sequential radiotherapy may achieve better curative effect in treatment of EGFR gene mutation in patients with lung cancer associated by bone metastasis.关键词
肺肿瘤/肿瘤转移/免疫疗法/受体,表皮生长因子Key words
Lung Neoplasms/Neoplasm Metastasis/Immunotherapy/Receptor/epidermal growth factor分类
医药卫生引用本文复制引用
苗栓林,曹晓朋,胡丽芳..表皮生长因子受体组织基因突变状态与自体细胞免疫联合序贯化放疗治疗肺癌骨转移效果的关系分析[J].解放军医药杂志,2018,30(2):1-4,4.基金项目
陕西省自然科学基金项目(2015JQ3076) （2015JQ3076）
