解放军医药杂志2018，Vol.30Issue(2)：5-8,4.DOI:10.3969/j.issn.2095-140X.2018.02.002
七氟烷与丙泊酚对老年肺癌根治术患者术后认知功能的影响
Effects of Sevoflurane and Propofol on Postoperative Cognitive Function in Elderly Patients with lung cancer af-ter Radical Resection
摘要
Abstract
Objective To analyze effects of Sevoflurane and Propofol on postoperative cognitive function in eld-erly patients with lung cancer undergoing radical resection. Methods A total of 124 elderly patients with lung cancer undergoing radical resection during August 2014 and May 2017 were divided into Sevoflurane group(n=62) and Propo-fol group (n=62) according to different anesthetic methods. Sevoflurane group was given Sevoflurane for intraoperative anesthesia maintenance,while Propofol group received Propofol for intraoperative anesthesia maintenance. Postoperative anesthesia and palinesthesia conditions,the mini-mental state examination(MMSE) score,incidence conditions of anxie-ty,depression and postoperative cognitive dysfunction(POCD) and serum S100β protein levels before and after operation were observed,and incidence rate of adverse reactions was recorded in two groups. Results Spontaneously breathing, beginning eye opening and extubation times in Sevoflurane group were significantly shorter than those in propofol group (P<0.05). MMSE scores at postoperative 6thh,1std and 3thd in Sevoflurane group were significantly higher than those in Propofol group (P<0.05). At postoperative 1std, self-rating depression scale (SDS) and self-rating anxiety scale (SAS) scores in Sevoflurane group were significantly lower than those in Propofol group(P<0.05). At postoperative 1st d and 3thd,POCD incidence rates in Sevoflurane group were significantly lower than those in Propofol group(P<0.05). At postoperative 10thmin,1std and 3thd, serum S100β protein levels in Sevoflurane group were significantly lower than those in Propofol group (P<0.05). There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05). Conclusion Sevoflurane in application of elderly patients with lung cancer undergoing radical resection for anesthesia maintenance may has little effect on POCD than that by Propofol,and it is beneficial to postopera-tive recovery of cognitive function.关键词
肺肿瘤/七氟烷/丙泊酚/老年人/认知障碍Key words
Lung Neoplasm/Sevoflurane/Propofol/Aged/Cognition disorders分类
医药卫生引用本文复制引用
陈海明,张红玉,张强..七氟烷与丙泊酚对老年肺癌根治术患者术后认知功能的影响[J].解放军医药杂志,2018,30(2):5-8,4.基金项目
河北省卫生厅课题项目(20171404) （20171404）
