解放军医药杂志2018，Vol.30Issue(2)：25-27,30,4.DOI:10.3969/j.issn.2095-140X.2018.02.007
慢性阻塞性肺疾病患者N末端脑钠肽原水平与肺功能、血气指标的相关性分析
Correlations Analysis between NT-proBNP Levels with Lung Function and Blood Gas Parameters in Patients with Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To analyze correlations between NT-proBNP levels and lung function and blood gas pa-rameters in patients with different degrees of COPD. Methods A total of 104 patients with COPD admitted during Janu-ary 2015 and December 2016 were divided into stable period group(n=52) and acute exacerbations period group(n=52) according to pathogenetic conditions,and other 52 healthy people taking physical examinations were selected as con-trol group. Serum N-terminal pro-brain natriuretic peptide(NT-proBNP) level,percentage of forced expiratory volume in one second (FEV1) to prediction value (FEV1%),FEV1/forced vital capacity (FVC) and arterial partial pressure of carbon dioxide(PaO2) levels were compared,and correlations between NT-proBNP level with indexes of pulmonary func-tion and arterial blood gas analysis were analyzed in three groups.Results Serum NT-proBNP levels in stable period and acute exacerbations period groups were significantly higher than that in control group(P<0.05),and the level in acute exacerbations period group was significantly higher than that in stable period group (P<0.05). Values of FEV1%, FEV1/FVC and PaO2level in stable period and acute exacerbations period groups were significantly lower,while PaCO2 level was significantly higher than those in control group (P <0.05); in acute exacerbations period group, the values were significantly lower,while PaCO2level was significantly higher than those in stable period group(P<0.05). Serum NT-proBNP level was negatively correlated with FEV1%, FEV1/FVC and PaO2levels (r = -0.694, -0.683 and-0.708, P=0.034,0.037 and 0.031),and it was positively correlated with PaCO2levels in COPD patients.Conclu-sion Serum NT-proBNP levels in COPD patients are significantly higher than those in healthy people,and the level can be decreased with improving lung function and blood gas indexes in patients with COPD.关键词
肺疾病,慢性阻塞性/血清N末端脑钠肽原/呼吸功能试验/血气分析Key words
Pulmonary disease/chronic obstructive/N-terminal pro-brain natriuretic peptide/Respiratory func-tion tests/Blood gas analysis分类
医药卫生引用本文复制引用
周梅芳,付娟娟..慢性阻塞性肺疾病患者N末端脑钠肽原水平与肺功能、血气指标的相关性分析[J].解放军医药杂志,2018,30(2):25-27,30,4.基金项目
国家自然基金项目(81400030) （81400030）
