解放军医药杂志2018，Vol.30Issue(2)：94-97,4.DOI:10.3969/j.issn.2095-140X.2018.02.025
托吡酯治疗脑梗死后继发癫痫临床效果及认知功能分析
Clinical Effectiveness of Topiramate in Treatment of Secondary Epilepsy after Cerebral Infarction and Its Effect on Cognitive Function
摘要
Abstract
Objective To investigate clinical effectiveness of Topiramate in treatment of secondary epilepsy after cerebral infarction. Methods A total of 134 patients with secondary epilepsy after cerebral infarction admitted during February 2013 and October 2016 were divided into observation group and control group(n=67 for each group) according to therapeutic methods. Observation group was treated with Topiramate,while control group was treated with Carbamaz-epine. Clinical effectiveness and abnormal electroencephalogram(EEG) rate were observed,and neurologic impairment conditions,activities of daily living and cognitive function were evaluated in two groups. Results In observation group, the total effective rate was significantly higher, while abnormal EEG rate was lower than those in control group (P<0.05). After treatment,scores of National Institutes of Health stroke scale(NIHSS) were significantly lower,while activities of daily living and cognitive function scores in two groups were significantly higher than those in control group, and improved conditions in observation group were superior than those in control group(P<0.05). Incidence rate of ad-verse effects in observation group was significantly lower than that in control group(P<0.05). Conclusion Topiramate in treatment of secondary epilepsy after cerebral infarction may achieve good effect and improve EEG and cognitive function.关键词
托吡酯/卡马西平/脑梗死/癫痫/认知Key words
Topiramate/Carbamazepine/Brain infarction/Epilepsy/Cognition分类
医药卫生引用本文复制引用
周艳辉,周峰,余丹,刘春苗,马琳..托吡酯治疗脑梗死后继发癫痫临床效果及认知功能分析[J].解放军医药杂志,2018,30(2):94-97,4.基金项目
海南省自然科学基金项目(20168300) （20168300）
