化工学报2018，Vol.69Issue(3)：1046-1052,7.DOI:10.11949/j.issn.0438-1157.20171147
阿司匹林结晶过程的在线分析
Online monitor of Aspirin crystallization process
摘要
Abstract
Size distribution and geometry are key properties of crystal products, which can affect product quality and downstream processes of filtration, drying, storage and transportation. An on-line process analysis system, including ultrasonic particle size analyzer, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), turbidity analyzer and two-dimensional imaging system, was developed to monitor crystallization of Aspirin ethanol solution at various stirring and cooling rates. The results show that lower cooling or faster stirring rate produces more amount of fine crystals and higher cooling rate yields product with larger mean size and higher aspect ratio (AR). Therefore, adjusting cooling and stirring rate is an effective technique to control particle size distribution and shape of Aspirin crystals.关键词
阿司匹林/结晶/在线测量/粒度分布/晶体形状Key words
Aspirin/crystallization/online measurement/particle size distribution/crystal shape分类
化学化工引用本文复制引用
李兰菊,李秀喜,徐三..阿司匹林结晶过程的在线分析[J].化工学报,2018,69(3):1046-1052,7.基金项目
国家自然科学基金项目(21376091).supported the National Natural Science Foundation of China(21376091). （21376091）
