中国实用神经疾病杂志2018，Vol.21Issue(1)：12-15,4.DOI:10.12083/SYSJ.2018.01.003
芹菜素对胶质瘤U87细胞的抗增殖作用及其机制研究
Apigenin inhibits glioma cell proliferation by activating Bak 1
摘要
Abstract
Objective To explore the inhibitory effect of apigenin on human glioma and its molecular mechanism .Methods Human glioma U87 cells were treated with 0 ,20 ,and 40 μmol/L apigenin .Cell proliferation was evaluated by MTT ,and apoptosis was detected by flow cytometry .U87 cells were further transfected with Bak1 siRNA ,and stimulated with apigenin after 24h .The proliferation and apoptosis of the cells were observed in vitro ,and the expression of Bak1 was detected by Western blot .Results Apigenin can effectively inhibit the grow th of glioma cells and induce apoptosis .After inhibiting the expression of Bak1 ,apigenin inhibited the proliferation of glioma cells ,and no cell apoptosis occurred .Conclusion Apigenin inhibits glioma cell growth and pro-motes apoptosis by activating Bak1 protein .关键词
芹菜素/胶质瘤/增殖/凋亡/Bak1Key words
Apigenin/Glioma/Proliferation/Apoptosis/Bak1分类
医药卫生引用本文复制引用
贡伟一,程峰,刘华,张曙光..芹菜素对胶质瘤U87细胞的抗增殖作用及其机制研究[J].中国实用神经疾病杂志,2018,21(1):12-15,4.基金项目
江苏大学 2016 年度医学临床科技发展基金(JL Y20160042 ) （JL Y20160042 ）
