中国实用神经疾病杂志2018，Vol.21Issue(1)：34-36,3.DOI:10.12083/SYSJ.2018.01.008
急性缺血性脑卒中静脉溶栓预后的影响因素分析
Analysis of prognostic factors after intravenous thrombolysis in acute ischemic stroke
摘要
Abstract
Objective To study the prognostic factors of intravenous thrombolytic therapy after acute ischemic stroke . Methods A total of 96 patients with acute ischemic stroke who underwent intravenous thrombolytic therapy from January 2015 to December 2016 in Guangdong province were enrolled in this study .The data of the patients were collected ,such as the age ,sex , weight ,history of hypertension ,history of diabetes mellitus ,history of smoking ,systolic pressure before thrombolysis ,blood glucose before thrombolysis ,onset-thrombolysis time ,NIHSS score before thrombolysis and prognosis .Results There were no significant differences in age ,sex ,weight ,history of hypertension ,history of smoking and smoking between the two groups (P>0.05) .Compared with the better prognosis group ,the poor prognosis group showed higher proportion of diabetes ,the systolic pressure before thrombolysis ,the premenstrual blood glucose ,onset-longer thrombolysis and higher NIHSS score before thrombol-ysis (P<0.05) .The Logistic regression analysis showed that diabetes (OR=11 ,P=0.001) ,thrombolytic blood glucose (OR=10 ,P=0.028) ,onset-thrombolysis (OR=4 ,P=0.032) ,thrombolysis (OR=1.01 ,P=0.013) ,NIHSS score before thrombolysis (OR= 1.28 ,P = 0.001 ) was significantly associated with poor thrombolytic outcome .Conclusion The history of diabetes mellitus ,systolic pressure before thrombolysis ,blood glucose before thrombolysis ,onset time-thrombolysis time ,NIHSS score be-fore thrombolysis are independent risk factors of poor prognosis in patients with acute ischemic stroke who underwent intravenous thrombolytic therapy .关键词
急性缺血性脑卒中/静脉溶栓/预后/阿替普酶/缺血半暗带Key words
Acute ischemic stroke/Intravenous thrombolysis/Prognosis/Alteplase/Ischemic penumbra分类
医药卫生引用本文复制引用
李华,梁维,余振威..急性缺血性脑卒中静脉溶栓预后的影响因素分析[J].中国实用神经疾病杂志,2018,21(1):34-36,3.基金项目
广东省科技项目(2016ZC0023 ) （2016ZC0023 ）
珠海市医学科研基金项目(2015J009) （2015J009）
