中国实用神经疾病杂志2018，Vol.21Issue(1)：40-43,4.DOI:10.12083/SYSJ.2018.01.010
替罗非班治疗阿替普酶静脉溶栓后再闭塞的疗效观察
Observation of the clinical effect of tirofiban treatment in patients with early reocclusion after alteplase intrave-nous thrombolysis of acute ischemic stroke
孙原 1石秋艳 1李艳玲 1杨斌 1张春阳 1李冬梅 1王翠兰 1李弘1
作者信息
- 1. 华北理工大学附属医院神经内科重症病房 ,河北 唐山 063000
- 折叠
摘要
Abstract
Objective To observe of the clinical efficacy and safety of tirofiban treatment in patients with early reocclusion after alteplase intravenous thrombolysis of acute ischemic stroke .Methods Patients with early reocclusion after were treated with alteplase intravenous thrombolysis within 4.5 hours of onset ,60 patients which were reocclusion after alteplase intravenous throm-bolysis ,were randomly divided into Group A (n=30) and Group B (n=30) .The patients in group B received tirofiban treatment (tirofiban was bolus injected with 5μg/kg in 3 minutes then continued at a dosage of 0.075μg/kg body weight/min at least 24h ) and group A as control .National Institutes of Health stroke scale (NIHSS) score before intravenous thrombolysis ,neurologic symptoms aggravated ,24h ,7d ,the modified Rankin scale (mRS) score after intravenous thrombolysis 90d were observed ,the mor-tality ,symptomatic cerebral hemorrhage were observed .Results NIHSS score of two groups of patients before thrombolysis and after thrombolysis neurologic symptoms aggravated(reocclusion)NIHSS score in both groups ,there was no significant difference (P>0.05) .But after 24h ,7d ,NIHSS scores between the two groups were significantly different (P<0.05) .At 90d from onset , mRS≤2 in the two groups were significantly different(P<0.05) .The mortality rate in the two groups had no significant differ-ence(P>0.05) .Symptoms of cerebral hemorrhage rate in the two groups had no significant difference (P>0.05) .Conclusion Tirofiban treatment in patients with early reocclusion after alteplase intravenous thrombolysis of acute ischemic stroke were effica-cy and safety .关键词
替罗非班/急性缺血性脑卒中/阿替普酶/再闭塞/有效性/安全性Key words
Tirofiban/Acute ischemic stroke/Alteplase/Reocclusion/Efficacy/Safety分类
医药卫生引用本文复制引用
孙原,石秋艳,李艳玲,杨斌,张春阳,李冬梅,王翠兰,李弘..替罗非班治疗阿替普酶静脉溶栓后再闭塞的疗效观察[J].中国实用神经疾病杂志,2018,21(1):40-43,4.
