摘要
Abstract
Objective To observe the effect of endovascular stent implantation assisting coil embolization in the treatment of patients with intracranial aneurysms .Methods A total of 114 cases with intracranial aneurysms in our hospital from August 2013 to October 2016 were divided into the control group and the observation group according to different operation methods ,57 cases in each group .The observation group was treated with endovascular stent implantation assisting coil embolization ,and the control group was treated with craniotomy clipping .The neurological deficit score (NIHSS) score and levels of serum sICAM-1 ,S100βprotein before and 1 week after operation ,and the quality of life score (QOL) before and 1 year after operation were compared be-tween the two groups .The incidence of postoperative complications and recurrence rate in 1 year after operation and prognosis were compared between the two groups .Results There was insignificant difference in NIHSS scores between the two groups be-fore operation(P>0.05) .1 week after operation ,the NIHSS scores of the two groups were lower than those before the operation , and the observation group was lower than the control group(P<0.05) .After 1 week ,the levels of serum sICAM-1 and S100βpro-tein of the two groups were lower than those before operation ,and the observation group was lower than the control group(P<0.05) .The incidence of postoperative complications in the observation group was 10.53％ (6/57) ,which was lower than that of the control group 24.56％ (14/57) ,and the difference was statistically significant (P< 0.05) .1 year after operation ,the QOL scores of two groups were all higher than those before operation ,and the observation group was higher than the control group(P<0.05) .The recurrence rate of the observation group after 1 year 1.75％ (1/57) was lower than that of the control group 14.04％(8/57) ,and the prognosis of the observation group was better than that of the control group .The difference was statistically sig-nificant(P<0.05) .Conclusion The application of endovascular stent implantation assisting coil embolization in patients with in-tracranial aneurysms has positive effect .It can effectively reduce the postoperative serum sICAM-1 ,S100 protein levels and neuro-logic functional damage ,reduce the occurrence of complications and recurrence ,and improve their quality of life and prognosis .关键词
颅内动脉瘤/血管内支架植入/弹簧圈栓塞/sICAM-1/S100β蛋白/复发率Key words
Intracranial aneurysm/Endovascular stent implantation/Coil embolization/sICAM-1/S100β protein/Recurrence rate分类
医药卫生
