中国实用神经疾病杂志2018，Vol.21Issue(2)：124-128,5.DOI:10.12083/SYSJ.2018.02.032
儿童抽动障碍影响因素的队列研究
Cohort study on the influencing factor in tic disorders for children
摘要
Abstract
Objective The research is aimed to explore the factors that affect TD symptoms and its recurrence for children . Methods We adopted cohort study strategy ,followed up and observed 80 cases of children with TD .Through survival analysis plus COX multiple regression ,we appraised every factor which affects TD symptoms' halt and recurrence for children .Results After following up each research factor ,we started the COX plus survival analysis model .Through the test of wals ,TD type , family history of TD ,family relationship ,mental trauma ,allergic factor ,diet factor ,and time spent on watching TV and playing games belong to P<0 .05 respectively and 95％ CI respectively excluding 1 .The differences were statistically significant .Age , gender ,non-specific change for electoroencephalogram ,mild anomaly for imaging examination ,penrinatal factor ,sleep disorder ,and head injuries belong to P>0.05 respectively ,and also 95％ CI including 1 .No matter what value is for RR value ,The differences were not statistically significant .In terms of treatment mode and comorbidity ,because of P>0.05 and 95％ CI excluding 1 ,we had to increase the sample size for the further research .After following up each research factor ,we started the COX plus survival analysis model after TD recurrence .Family history of TD ,family relationship ,mental trauma ,allergic factor ,diet factor ,time spent on watching TV and playing games ,and comorbidity were because of P<0.05 respectively ,and 95％ CI excluding 1 .The differ-ences were statistically significant .Factors such as TD type ,gender ,non-specific change for electoroencephalogram ,mild anomaly for imaging examination ,penrinatal factor ,sleep disorder ,and head injuries were because of P>0.05 respectively and also 95％ CI including 1 .No matter what value was for RR value ,the differences were statistical significance .In terms of treatment mode and family history of TD ,because of P>0.05 and 95％ CI excluding 1 ,we had to increase the sample size for the further research . Conclusion Factors such as TD type ,family history of TD ,family relationship ,mental trauma ,allergic factor ,diet factor ,and time spent on watching TV and playing games ,which are all risky ones ,are not conducive to the relief of the symptoms .Factors such as family relationship ,mental trauma ,allergic factor ,diet factor ,and time spent on watching TV and playing games ,and comorbidity , which belong to risky ones for TD recurrence ,are conducive to the recurrence of the symptoms .关键词
抽动障碍/儿童/复发/随访/COX回归/生存分析/影响因素Key words
Tic disorders/Children/Recurrence/Follow-up/COX regression/Survival analysis/Influencing factor分类
医药卫生引用本文复制引用
陈敏,图雅,杨慧敏..儿童抽动障碍影响因素的队列研究[J].中国实用神经疾病杂志,2018,21(2):124-128,5.基金项目
内蒙古自治区卫计委医学科研项目(201303021) （201303021）
