中国实用神经疾病杂志2018，Vol.21Issue(3)：233-238,6.DOI:10.12083/SYSJ.2018.03.061
动态血压相关脑白质损伤的磁共振弥散张量研究
Diffusion tensor imaging study on MRI of white matter damage associated with ambulatory blood pressure
摘要
Abstract
Objective By using diffusion tensor imaging (DTI)to study the impact of blood pressure variability on the white matter of hypertensive patients with normal MRI results ,to observe the characteristics and relative dangerous factors of early ul-trastructural damage of white matter in hypertensive patients .Methods Selecting 26 cases of patients with primary hypertension as the hypertension group ;19 cases of healthy patients as the control group ,to analyze the fractional anisotropy(FA) ,mean diffu-sion coefficient(MD)of different locations of white matter ,and the correlation of FA ,MD values with the blood pressures variabili-ty parameters .Results Comparison of the ambulatory blood pressure parameters between the two groups :24hSBP ,dSBP ,and nSBP levels of the hypertension group were significantly higher ,with statistically significant difference ;statistically significant difference was also found between the two groups in 24hSBP-CV ,dSBP-CV ,valley and peak values of 24hSBP .The non-dipper blood pressure rhythm of the hypertension group up to 38.45％ was significantly higher than that of the control group .Compari-son of the DTI parameters in ROI area at the same locations between the two groups :FA ,MD values were significantly different between the two groups in the anterior and posterior horns of the lateral ventricle and the centrum semiovale ;Only FA values were significantly different between the two groups in the sbucortex white matter area of the frontal lobe and the body of lateral ventri-cle ,while FA ,MD values in subcortex white matter of the temporal lobe ,parietal lobe ,occipital lobe showed no significant differ-ences between the two groups .Conclusion Early damage caused by hypertension to white matter was mainly found in the anterior horn ,posterior horn of lateral ventricle ,and the centrum semiovle .Certain extent of damage was also found in the subcortex white matter area of the frontal lobe and the body of lateral ventricle .Elevated blood pressure ,blood pressure variability were all factors that may cause white matter damage .关键词
缺血性脑白质病变/高血压/动态血压/弥散张量成像/FA/MDKey words
Ischemic white matter lesions/Hypertension/Ambulatory blood pressure/Diffusion tensor imaging/FA/MD分类
医药卫生引用本文复制引用
赵曼丽,郭鹏,兰希福,赵玉璇..动态血压相关脑白质损伤的磁共振弥散张量研究[J].中国实用神经疾病杂志,2018,21(3):233-238,6.基金项目
山东省潍坊市卫生和计划生育委员会中医药科研项目计划(2015002) （2015002）
