中国实用神经疾病杂志2018，Vol.21Issue(3)：247-252,6.DOI:10.12083/SYSJ.2018.03.064
重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死疗效分析
Analysis of therapeutic effect in the treatment of acute cerebral infarction by recombinant tissue plasminogen ac-tivator
摘要
Abstract
Objective To investigate the clinical efficacy of rt-pA intravenous thrombolysis in patients with acute cerebral infarction and the risk of bleeding and death .Methods A total of 258 patients with acute cerebral infarction who were treated in 4 . 5H were retrospectively analyzed .They were divided into intravenous thrombolytic therapy group(thrombolysis group)and control group according to whether rt-PA thrombolysis was performed .196 patients in the thrombolytic group were given rt-PA by 0.9mg kg -1 (the maximum number of no more than 90mg) ,and the two groups were given the routine treatment of cerebral infarction . The NIHSS score ,clinical efficacy ,bleeding and death in the two groups were compared .Results The NIHSS score and clinical effect of the thrombolysis group were better than those of the control group after treatment ,the difference was statistically signifi-cant (P<0.05) ,and there was no significant difference in intracranial hemorrhage risk between the two groups (P>0.05) .The mortality of thrombolytic group was lower than that of the control group ,and the difference was statistically significant (P<0.05) .Conclusion The application of rt-PA intravenous thrombolysis in 4.5h for patients with acute cerebral infarction has sig-nificant clinical effect ,and it does not increase the risk of intracranial hemorrhage and risk of death .关键词
急性脑梗死/时间窗/rt-PA/静脉溶栓/颅内出血Key words
Acute cerebral infarction/Time window/rt-PA/Intravenous thrombolysis/Intracranial hemorrhage分类
医药卫生引用本文复制引用
石炎川,蔡若蔚,陈跃鸿,王凌星,杨妙雄,郭婷辉..重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死疗效分析[J].中国实用神经疾病杂志,2018,21(3):247-252,6.基金项目
福建省卫生计生委中青年骨干人才培养项目(2016-ZQN-53) （2016-ZQN-53）
福建省自然科学基金项目(2015J01449) （2015J01449）
