中国实用神经疾病杂志2018，Vol.21Issue(3)：261-265,5.DOI:10.12083/SYSJ.2018.03.067
静脉溶栓桥接机械取栓治疗房颤脑栓塞临床研究
Clinical study on combined intravenous thrombolysis and mechanical thrombectomy for cerebral infarction pa-tients with atrial fibrillation
摘要
Abstract
Objective To investigate the safety and effectiveness of combined Intravenous thrombolysis and mechanical thrombectomy(IVT and MT)in cerebral infarction patients with atrial fibrillation(AF) .Methods The clinical data of 43 patients with acute cerebral infarction and less than 4.5 h of symptom onset combined with AF from September 2015 to October 2017 in Nanyang Central Hospital were collected ;of them ,28 cases received IVT and MT ,and 15 cases received MT alone .A retrospective analysis was conducted on the onset to emergency (OTE)time ,emergency to acupuncture(ETA)time ,acupuncture to recanalization (ATR)time ,the recanalization rate ,the change of the National Institutes of Health Stroke Scale (NIHSS)score ,the better prognosis rate at 90 days ,the number of passes with stent retriever ,symptomatic intracranial hemorrhage (SICH )and mortality . Results There was no statistically difference in the OTE time ,the ETA time .The SICH and mortality were also similar among groups .The difference was statistically significant in the ATR time ,the change of NIHSS score ,the better prognosis rate at 90 days and the number of passes .Conclusion For cerebral infarction patients with atrial fibrillation ,the treatment of IVT and MT is similar to that of MT alone in symptomatic intracranial hemorrhage and mortality ,but the ATR time of the IVT and MT is shor-ter ,the early efficacy and 90d favorable prognosis is better than that of M T alone .关键词
房颤/脑栓塞/静脉溶栓桥接机械取栓/单纯机械取栓/阿替普酶Key words
Atrial fibrillation/cerebral infarction/Combined intravenous thrombolysis and mechanical thrombectomy/Me-chanical/Thrombectomy alone/rt-PA分类
医药卫生引用本文复制引用
张肖,张保朝..静脉溶栓桥接机械取栓治疗房颤脑栓塞临床研究[J].中国实用神经疾病杂志,2018,21(3):261-265,5.基金项目
北京医卫健康公益基金会医学科学研究基金资助项目(YWJKJJHKYJJ-B17781) （YWJKJJHKYJJ-B17781）
